E3 ubiquitin-protein ligase TRIM63 is an enzyme that in humans is encoded by the TRIM63gene.
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.
^ abCentner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (Mar 2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". J Mol Biol306 (4): 717–26. doi:10.1006/jmbi.2001.4448. PMID11243782.
^ abDai KS, Liew CC (Jun 2001). "A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain". J Biol Chem276 (26): 23992–9. doi:10.1074/jbc.M011208200. PMID11283016.
Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.". Mol. Vis.8: 185–95. PMID12107412.
Pizon V, Iakovenko A, Van Der Ven PF, et al. (2003). "Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein.". J. Cell. Sci.115 (Pt 23): 4469–82. doi:10.1242/jcs.00131. PMID12414993.
Witt SH, Granzier H, Witt CC, Labeit S (2005). "MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.". J. Mol. Biol.350 (4): 713–22. doi:10.1016/j.jmb.2005.05.021. PMID15967462.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature441 (7091): 315–21. doi:10.1038/nature04727. PMID16710414.
Doucet M, Russell AP, Léger B, et al. (2007). "Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.". Am. J. Respir. Crit. Care Med.176 (3): 261–9. doi:10.1164/rccm.200605-704OC. PMID17478621.