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Tripartite motif containing 63, E3 ubiquitin protein ligase
Protein TRIM63 PDB 2d8u.png
PDB rendering based on 2d8u.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TRIM63 ; IRF; MURF1; MURF2; RNF28; SMRZ
External IDs OMIM606131 MGI2447992 HomoloGene41878 GeneCards: TRIM63 Gene
RNA expression pattern
PBB GE TRIM63 gnf1h00833 at tn.png
More reference expression data
Species Human Mouse
Entrez 84676 433766
Ensembl ENSG00000158022 ENSMUSG00000028834
UniProt Q969Q1 Q38HM4
RefSeq (mRNA) NM_032588 NM_001039048
RefSeq (protein) NP_115977 NP_001034137
Location (UCSC) Chr 1:
26.38 – 26.39 Mb
Chr 4:
134.32 – 134.33 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase TRIM63 is an enzyme that in humans is encoded by the TRIM63 gene.[1][2][3]

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.[3]


TRIM63 has been shown to interact with Titin,[1] GMEB1[4] and SUMO2.[2]


  1. ^ a b Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (Mar 2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". J Mol Biol 306 (4): 717–26. doi:10.1006/jmbi.2001.4448. PMID 11243782. 
  2. ^ a b Dai KS, Liew CC (Jun 2001). "A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain". J Biol Chem 276 (26): 23992–9. doi:10.1074/jbc.M011208200. PMID 11283016. 
  3. ^ a b "Entrez Gene: TRIM63 tripartite motif-containing 63". 
  4. ^ McElhinny AS, Kakinuma K, Sorimachi H, Labeit S, Gregorio CC (April 2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J. Cell Biol. 157 (1): 125–36. doi:10.1083/jcb.200108089. PMC 2173255. PMID 11927605. 

Further reading[edit]