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Tripartite motif containing 68
Symbols TRIM68 ; GC109; RNF137; SS-56; SS56
External IDs OMIM613184 MGI2142077 HomoloGene9991 GeneCards: TRIM68 Gene
RNA expression pattern
PBB GE TRIM68 219405 at tn.png
PBB GE TRIM68 gnf1h05427 s at tn.png
More reference expression data
Species Human Mouse
Entrez 55128 101700
Ensembl ENSG00000167333 ENSMUSG00000073968
UniProt Q6AZZ1 Q8K243
RefSeq (mRNA) NM_018073 NM_198012
RefSeq (protein) NP_060543 NP_932129
Location (UCSC) Chr 11:
4.62 – 4.63 Mb
Chr 7:
102.68 – 102.69 Mb
PubMed search [1] [2]

Tripartite motif-containing protein 68 is a protein that in humans is encoded by the TRIM68 gene.[1][2]

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.[2]


TRIM68 has been shown to interact with Androgen receptor.[3]


  1. ^ Chang GT, Steenbeek M, Schippers E, Blok LJ, van Weerden WM, van Alewijk DC, Eussen BH, van Steenbrugge GJ, Brinkmann AO (Oct 2001). "A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells". Eur J Cancer 37 (16): 2129–34. doi:10.1016/S0959-8049(01)00259-3. PMID 11597395. 
  2. ^ a b "Entrez Gene: TRIM68 tripartite motif-containing 68". 
  3. ^ Miyajima, Naoto; Maruyama Satoru; Bohgaki Miyuki; Kano Satoshi; Shigemura Masahiko; Shinohara Nobuo; Nonomura Katsuya; Hatakeyama Shigetsugu (May 2008). "TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells". Cancer Res. (United States) 68 (9): 3486–94. doi:10.1158/0008-5472.CAN-07-6059. PMID 18451177. 

Further reading[edit]