TRMU

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TRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Identifiers
Symbols TRMU ; MTO2; MTU1; TRMT; TRMT1; TRNT1
External IDs OMIM610230 MGI1919276 HomoloGene5589 GeneCards: TRMU Gene
EC number 2.1.1.61
RNA expression pattern
PBB GE TRMU 213634 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55687 72026
Ensembl ENSG00000100416 ENSMUSG00000022386
UniProt O75648 Q9DAT5
RefSeq (mRNA) NM_001008569 NM_028063
RefSeq (protein) NP_001269711 NP_082339
Location (UCSC) Chr 22:
46.73 – 46.75 Mb
Chr 15:
85.88 – 85.9 Mb
PubMed search [1] [2]

Mitochondrial tRNA-specific 2-thiouridylase 1 is an enzyme that in humans is encoded by the TRMU gene.[1][2]

This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.[2]

References[edit]

  1. ^ Yan Q, Guan MX (Jan 2004). "Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase". Biochim Biophys Acta 1676 (2): 119–26. doi:10.1016/j.bbaexp.2003.11.010. PMID 14746906. 
  2. ^ a b "Entrez Gene: TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase". 

Further reading[edit]