From Wikipedia, the free encyclopedia
Jump to: navigation, search
TRNA nucleotidyl transferase, CCA-adding, 1
Protein TRNT1 PDB 1ou5.png
PDB rendering based on 1ou5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TRNT1 ; CCA1; MtCCA
External IDs OMIM612907 MGI1917297 HomoloGene9333 GeneCards: TRNT1 Gene
EC number
Species Human Mouse
Entrez 51095 70047
Ensembl ENSG00000072756 ENSMUSG00000013736
UniProt Q96Q11 Q8K1J6
RefSeq (mRNA) NM_016000 NM_001242358
RefSeq (protein) NP_886552 NP_001229287
Location (UCSC) Chr 3:
3.17 – 3.19 Mb
Chr 6:
106.77 – 106.78 Mb
PubMed search [1] [2]

tRNA-nucleotidyltransferase 1, is an enzyme that in humans is encoded by the TRNT1 gene.[1][2][3] This enzyme adds the nucleotide sequence CCA to the 3' end of tRNA, using ATP and CTP as substrates. The sequence creates the binding site for an amino acid.[4]


  1. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093. 
  2. ^ Nagaike T, Suzuki T, Tomari Y, Takemoto-Hori C, Negayama F, Watanabe K, Ueda T (Oct 2001). "Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases". J Biol Chem 276 (43): 40041–9. doi:10.1074/jbc.M106202200. PMID 11504732. 
  3. ^ "Entrez Gene: TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1". 
  4. ^ Lizano E, Scheibe M, Rammelt C, Betat H, Mörl M (May 2008). "A comparative analysis of CCA-adding enzymes from human and E. coli: differences in CCA addition and tRNA 3'-end repair". Biochimie 90 (5): 762–72. doi:10.1016/j.biochi.2007.12.007. PMID 18226598. 

Further reading[edit]