Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.
Model organisms [ edit ]
Model organisms have been used in the study of TRPC4AP function. A conditional knockout mouse line, called Trpc4ap tm1a(KOMP)Wtsi [6 ] was generated as part of the [7 ] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. [8 ] [9 ] [10 ]
Male and female animals underwent a standardized
phenotypic screen to determine the effects of deletion. [4 ] Twenty five tests were carried out on [11 ] mutant mice and three significant abnormalities were observed. Few [4 ] homozygous mutant embryos were identified during gestation, and thus fewer than expected survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; females had an abnormal anagen phase of the hair cycle. [4 ]
Interactions [ edit ]
TRPC4AP has been shown to
interact with TNFRSF1A. [12 ]
See also [ edit ]
Further reading [ edit ]
This section is empty. You can help by adding to it. (July 2010)
References [ edit ]
^ "Dysmorphology data for Trpc4ap". Wellcome Trust Sanger Institute.
^ ". Wellcome Trust Sanger Institute. Salmonella infection data for Trpc4ap"
^ ". Wellcome Trust Sanger Institute. Citrobacter infection data for Trpc4ap"
^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi: 10.1111/j.1755-3768.2010.4142.x.
^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
^ "International Knockout Mouse Consortium".
^ "Mouse Genome Informatics".
^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi: 10.1038/nature10163. PMC 3572410. PMID 21677750.
^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi: 10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018. PMID 17218247.
^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi: 10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
^ Soond, Surinder M; Terry Jennifer L; Colbert Jeff D; Riches David W H (Nov 2003). "TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB". Mol. Cell. Biol. (United States) 23 (22): 8334–44. doi: 10.1128/MCB.23.22.8334-8344.2003. ISSN 0270-7306. PMC 262424. PMID 14585990.