TRPC6
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| Transient receptor potential cation channel, subfamily C, member 6 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TRPC6; FSGS2; TRP6 | ||||||||||||
| External IDs | OMIM: 603652 MGI: 109523 HomoloGene: 37944 IUPHAR: TRPC6 GeneCards: TRPC6 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7225 | 22068 | |||||||||||
| Ensembl | ENSG00000137672 | ENSMUSG00000031997 | |||||||||||
| UniProt | Q9Y210 | Q61143 | |||||||||||
| RefSeq (mRNA) | NM_004621.5 | NM_013838.2 | |||||||||||
| RefSeq (protein) | NP_004612.2 | NP_038866.2 | |||||||||||
| Location (UCSC) | Chr 11: 101.32 – 101.74 Mb |
Chr 9: 8.54 – 8.68 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).[1]
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[edit] Interactions
TRPC6 has been shown to interact with TRPC2,[2] FYN,[3] and TRPC3.[4]
[edit] Ligands
Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum (St. John's Wort) are hyperforin and adhyperforin.[5][6] These compounds are inhibitors of the reuptake of serotonin, norepinephrine (noradrenaline) and epinephrine (adrenaline), dopamine, gamma-aminobutyric acid (GABA), and glutamate, and they exert these effects by binding to and activating TRPC6.[6][7] Activation of TRPC6 induces the entry of calcium (Ca2+) and sodium (Na+) into the cell, which results in the reuptake inhibition.[7]
[edit] References
- ^ Winn MP, Conlon PJ, Lynn KL, et al. (2005). "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis". Science 308 (5729): 1801–4. doi:10.1126/science.1106215. PMID 15879175.
- ^ Chu, Xin; Tong Qin, Cheung Joseph Y, Wozney Jocelyn, Conrad Kathleen, Mazack Virginia, Zhang Wenyi, Stahl Richard, Barber Dwayne L, Miller Barbara A (Mar. 2004). "Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx". J. Biol. Chem. (United States) 279 (11): 10514–22. doi:10.1074/jbc.M308478200. ISSN 0021-9258. PMID 14699131.
- ^ Hisatsune, Chihiro; Kuroda Yukiko, Nakamura Kyoko, Inoue Takafumi, Nakamura Takeshi, Michikawa Takayuki, Mizutani Akihiro, Mikoshiba Katsuhiko (Apr. 2004). "Regulation of TRPC6 channel activity by tyrosine phosphorylation". J. Biol. Chem. (United States) 279 (18): 18887–94. doi:10.1074/jbc.M311274200. ISSN 0021-9258. PMID 14761972.
- ^ Hofmann, Thomas; Schaefer Michael, Schultz Günter, Gudermann Thomas (May. 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (11): 7461–6. doi:10.1073/pnas.102596199. ISSN 0027-8424. PMC 124253. PMID 12032305. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124253.
- ^ Müller WE, Singer A, Wonnemann M (2001). "Hyperforin--antidepressant activity by a novel mechanism of action". Pharmacopsychiatry. 34 Suppl 1: S98–102. PMID 11518085.
- ^ a b Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE (1998). "Hyperforin as a possible antidepressant component of hypericum extracts". Life Sci. 63 (6): 499–510. doi:10.1016/S0024-3205(98)00299-9. PMID 9718074.
- ^ a b Leuner K, Kazanski V, Müller M, et al (December 2007). "Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels". The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21 (14): 4101–11. doi:10.1096/fj.07-8110com. PMID 17666455.
[edit] Further reading
- Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes". Cell Calcium 33 (5–6): 533–40. doi:10.1016/S0143-4160(03)00058-7. PMID 12765698.
- Walz G (2006). "Slit or pore? A mutation of the ion channel TRPC6 causes FSGS". Nephrol. Dial. Transplant. 20 (9): 1777–9. doi:10.1093/ndt/gfh961. PMID 15998650.
- Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
- Schlöndorff JS, Pollak MR (2007). "TRPC6 in glomerular health and disease: what we know and what we believe". Semin. Cell Dev. Biol. 17 (6): 667–74. doi:10.1016/j.semcdb.2006.11.003. PMC 2705932. PMID 17116414. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2705932.
- Dietrich A, Gudermann T (2007). TRPC6. "TRPC6". Handb Exp Pharmacol. Handbook of Experimental Pharmacology 179 (179): 125–41. doi:10.1007/978-3-540-34891-7_7. ISBN 978-3-540-34889-4. PMID 17217054.
[edit] External links
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