TRPC6

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Transient receptor potential cation channel, subfamily C, member 6
Identifiers
Symbols TRPC6 ; FSGS2; TRP6
External IDs OMIM603652 HomoloGene37944 IUPHAR: 491 GeneCards: TRPC6 Gene
Orthologs
Species Human Mouse
Entrez 7225 22068
Ensembl ENSG00000137672 ENSMUSG00000031997
UniProt Q9Y210 Q61143
RefSeq (mRNA) NM_004621 NM_001282086
RefSeq (protein) NP_004612 NP_001269015
Location (UCSC) Chr 11:
101.32 – 101.74 Mb
Chr 9:
8.54 – 8.68 Mb
PubMed search [1] [2]

Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).[1]

Interactions[edit]

TRPC6 has been shown to interact with:

Ligands[edit]

Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin.[5][6] These compounds are inhibitors of the reuptake of serotonin, norepinephrine and epinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they exert these effects by binding to and activating TRPC6.[6][7] Activation of TRPC6 induces the entry of Ca2+ and Na+ into the cell, which results in the inhibition of reuptake.[7]

References[edit]

  1. ^ Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF et al. (2005). "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis". Science 308 (5729): 1801–4. doi:10.1126/science.1106215. PMID 15879175. 
  2. ^ Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T et al. (Apr 2004). "Regulation of TRPC6 channel activity by tyrosine phosphorylation". J. Biol. Chem. 279 (18): 18887–94. doi:10.1074/jbc.M311274200. PMID 14761972. 
  3. ^ Chu X, Tong Q, Cheung JY, Wozney J, Conrad K, Mazack V et al. (March 2004). "Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx". J. Biol. Chem. 279 (11): 10514–22. doi:10.1074/jbc.M308478200. PMID 14699131. 
  4. ^ Hofmann T, Schaefer M, Schultz G, Gudermann T (May 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7461–6. doi:10.1073/pnas.102596199. PMC 124253. PMID 12032305. 
  5. ^ Müller WE, Singer A, Wonnemann M (2001). "Hyperforin--antidepressant activity by a novel mechanism of action". Pharmacopsychiatry. 34 Suppl 1: S98–102. doi:10.1055/s-2001-15512. PMID 11518085. 
  6. ^ a b Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE (1998). "Hyperforin as a possible antidepressant component of hypericum extracts". Life Sci. 63 (6): 499–510. doi:10.1016/S0024-3205(98)00299-9. PMID 9718074. 
  7. ^ a b Leuner K, Kazanski V, Müller M, Essin K, Henke B, Gollasch M et al. (December 2007). "Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels". FASEB J. 21 (14): 4101–11. doi:10.1096/fj.07-8110com. PMID 17666455. 

Further reading[edit]

External links[edit]