|Transient receptor potential cation channel, subfamily M, member 3|
|Symbols||; GON-2; LTRPC3; MLSN2|
|External IDs||IUPHAR: GeneCards:|
|RNA expression pattern|
The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified. TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in pancreatic beta cell. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis.
- Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol Rev 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
- "Entrez Gene: TRPM3 transient receptor potential cation channel, subfamily M, member 3".
- Wagner TF, Loch S, Lambert S, et al. (November 2008). "Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells". Nature Cell Biology 10 (12): 1421–30. doi:10.1038/ncb1801. PMID 18978782.
- Oberwinkler J, Phillipp SE (2007). "TRPM3.". Handb Exp Pharmacol 179 (179): 253–67. doi:10.1007/978-3-540-34891-7_15. PMID 17217062.
- Harteneck C, Reiter B (2007). "TRP channels activated by extracellular hypo-osmoticity in epithelia.". Biochem. Soc. Trans. 35 (Pt 1): 91–5. doi:10.1042/BST0350091. PMID 17233610.
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