Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5gene.
TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+. Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consequentual hyperparathyroidism, and bone loss.
This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel , TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.
^Müller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (Sep 2000). "Gene structure and chromosomal mapping of human epithelial calcium channel". Biochem. Biophys. Res. Commun.275 (1): 47–52. doi:10.1006/bbrc.2000.3227. PMID10944439.Vancouver style error (help)CS1 maint: Date and year (link)
^Müller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI et al. (Nov 2000). "Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1)". Genomics67 (1): 48–53. doi:10.1006/geno.2000.6203. PMID10945469.Vancouver style error (help)CS1 maint: Date and year (link)
^Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev.57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID16382100.CS1 maint: Date and year (link)