TRPV5
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| Transient receptor potential cation channel, subfamily V, member 5 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TRPV5; CAT2; ECAC1; OTRPC3 | ||||||||||||
| External IDs | OMIM: 606679 MGI: 2429764 HomoloGene: 10520 IUPHAR: TRPV5 GeneCards: TRPV5 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 56302 | 194352 | |||||||||||
| Ensembl | ENSG00000127412 | ENSMUSG00000036899 | |||||||||||
| UniProt | Q9NQA5 | Q2TB50 | |||||||||||
| RefSeq (mRNA) | NM_019841.4 | NM_001007572.2 | |||||||||||
| RefSeq (protein) | NP_062815.2 | NP_001007573.1 | |||||||||||
| Location (UCSC) | Chr 7: 142.61 – 142.63 Mb |
Chr 6: 41.6 – 41.63 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene.[1][2][3]
TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+[4].. Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consquentual hyperparathyroidism, and bone loss[5]..
This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel , TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.[6]
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[edit] See also
[edit] Interactions
TRPV5 has been shown to interact with S100A10.[7]
[edit] References
- ^ Muller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (Sep 2000). "Gene structure and chromosomal mapping of human epithelial calcium channel". Biochem Biophys Res Commun 275 (1): 47–52. doi:10.1006/bbrc.2000.3227. PMID 10944439.
- ^ Muller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI, Eggert P, Garcia-Nieto V, Claverie-Martin F, Bindels RJ (Nov 2000). "Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1)". Genomics 67 (1): 48–53. doi:10.1006/geno.2000.6203. PMID 10945469.
- ^ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol Rev 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
- ^ Hoenderop,J.G.; Nilius,B.; Bindels,R.J. (2002). "Molecular mechanism of active Ca2+ reabsorption in the distal nephron". Annu. Rev Physiol. 64: 529–49. doi:10.1146/annurev.physiol.64.081501.155921. PMID 11826278.
- ^ Hoenderop,J.G.; van Leeuwen,J.P.; van der Eerden,B.C.; Kersten,F.F.; van der Kemp,A.W.; Merillat,A.M.; Waarsing,J.H.; Rossier,B.C.; Vallon,V.; Hummler,E.; Bindels,R.J. (2003). "Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5". J.Clin.Invest 112 (12): 1906–14. doi:10.1172/JCI19826. PMC 297001. PMID 14679186. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=297001.
- ^ "Entrez Gene: TRPV5 transient receptor potential cation channel, subfamily V, member 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56302.
- ^ van de Graaf, Stan F J; Hoenderop Joost G J, Gkika Dimitra, Lamers Dennis, Prenen Jean, Rescher Ursula, Gerke Volker, Staub Olivier, Nilius Bernd, Bindels René J M (Apr. 2003). "Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10–annexin 2 complex". EMBO J. (England) 22 (7): 1478–87. doi:10.1093/emboj/cdg162. ISSN 0261-4189. PMC 152906. PMID 12660155. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152906.
[edit] Further reading
- Vennekens R, Droogmans G, Nilius B (2002). "Functional properties of the epithelial Ca2+ channel, ECaC". Gen. Physiol. Biophys. 20 (3): 239–53. PMID 11765215.
- Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes". Cell Calcium 33 (5–6): 533–40. doi:10.1016/S0143-4160(03)00058-7. PMID 12765698.
- Nijenhuis T, Hoenderop JG, Bindels RJ (2006). "TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate". Pflugers Arch. 451 (1): 181–92. doi:10.1007/s00424-005-1430-6. PMID 16044309.
- Mensenkamp AR, Hoenderop JG, Bindels RJ (2007). "TRPV5, the gateway to Ca2+ homeostasis". Handb Exp Pharmacol. Handbook of Experimental Pharmacology 179 (179): 207–20. doi:10.1007/978-3-540-34891-7_12. ISBN 978-3-540-34889-4. PMID 17217059.
- Schoeber JP, Hoenderop JG, Bindels RJ (2007). "Concerted action of associated proteins in the regulation of TRPV5 and TRPV6". Biochem. Soc. Trans. 35 (Pt 1): 115–9. doi:10.1042/BST0350115. PMID 17233615.
[edit] External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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