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Transient receptor potential cation channel, subfamily V, member 5
Symbols TRPV5 ; CAT2; ECAC1; OTRPC3
External IDs OMIM606679 MGI2429764 HomoloGene10520 IUPHAR: TRPV5 ChEMBL: 1628474 GeneCards: TRPV5 Gene
RNA expression pattern
PBB GE TRPV5 208267 at tn.png
More reference expression data
Species Human Mouse
Entrez 56302 194352
Ensembl ENSG00000127412 ENSMUSG00000036899
UniProt Q9NQA5 P69744
RefSeq (mRNA) NM_019841 NM_001007572
RefSeq (protein) NP_062815 NP_001007573
Location (UCSC) Chr 7:
142.61 – 142.63 Mb
Chr 6:
41.65 – 41.68 Mb
PubMed search [1] [2]

Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene.[1][2][3]

TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+.[4] Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consequentual hyperparathyroidism, and bone loss.[5]

This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel , TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.[6]

See also[edit]


TRPV5 has been shown to interact with S100A10.[7]


  1. ^ Muller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (Sep 2000). "Gene structure and chromosomal mapping of human epithelial calcium channel". Biochem Biophys Res Commun 275 (1): 47–52. doi:10.1006/bbrc.2000.3227. PMID 10944439. 
  2. ^ Muller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI, Eggert P, Garcia-Nieto V, Claverie-Martin F, Bindels RJ (Nov 2000). "Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1)". Genomics 67 (1): 48–53. doi:10.1006/geno.2000.6203. PMID 10945469. 
  3. ^ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol Rev 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  4. ^ Hoenderop,J.G.; Nilius,B.; Bindels,R.J. (2002). "Molecular mechanism of active Ca2+ reabsorption in the distal nephron". Annu. Rev Physiol. 64: 529–49. doi:10.1146/annurev.physiol.64.081501.155921. PMID 11826278. 
  5. ^ Hoenderop,J.G.; van Leeuwen,J.P.; van der Eerden,B.C.; Kersten,F.F.; van der Kemp,A.W.; Merillat,A.M.; Waarsing,J.H.; Rossier,B.C.; Vallon,V.; Hummler,E.; Bindels,R.J. (2003). "Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5". J.Clin.Invest 112 (12): 1906–14. doi:10.1172/JCI19826. PMC 297001. PMID 14679186. 
  6. ^ "Entrez Gene: TRPV5 transient receptor potential cation channel, subfamily V, member 5". 
  7. ^ van de Graaf, Stan F J; Hoenderop Joost G J; Gkika Dimitra; Lamers Dennis; Prenen Jean; Rescher Ursula; Gerke Volker; Staub Olivier; Nilius Bernd; Bindels René J M (Apr 2003). "Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10–annexin 2 complex". EMBO J. (England) 22 (7): 1478–87. doi:10.1093/emboj/cdg162. ISSN 0261-4189. PMC 152906. PMID 12660155. 

Further reading[edit]

  • Vennekens R, Droogmans G, Nilius B (2002). "Functional properties of the epithelial Ca2+ channel, ECaC". Gen. Physiol. Biophys. 20 (3): 239–53. PMID 11765215. 
  • Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes". Cell Calcium 33 (5–6): 533–40. doi:10.1016/S0143-4160(03)00058-7. PMID 12765698. 
  • Nijenhuis T, Hoenderop JG, Bindels RJ (2006). "TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate". Pflugers Arch. 451 (1): 181–92. doi:10.1007/s00424-005-1430-6. PMID 16044309. 
  • Mensenkamp AR, Hoenderop JG, Bindels RJ (2007). "TRPV5, the gateway to Ca2+ homeostasis". Handb Exp Pharmacol. Handbook of Experimental Pharmacology 179 (179): 207–20. doi:10.1007/978-3-540-34891-7_12. ISBN 978-3-540-34889-4. PMID 17217059. 
  • Schoeber JP, Hoenderop JG, Bindels RJ (2007). "Concerted action of associated proteins in the regulation of TRPV5 and TRPV6". Biochem. Soc. Trans. 35 (Pt 1): 115–9. doi:10.1042/BST0350115. PMID 17233615. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.