TRPV5

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Transient receptor potential cation channel, subfamily V, member 5
Identifiers
Symbols TRPV5 ; CAT2; ECAC1; OTRPC3
External IDs OMIM606679 MGI2429764 HomoloGene10520 IUPHAR: TRPV5 ChEMBL: 1628474 GeneCards: TRPV5 Gene
RNA expression pattern
PBB GE TRPV5 208267 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 56302 194352
Ensembl ENSG00000127412 ENSMUSG00000036899
UniProt Q9NQA5 P69744
RefSeq (mRNA) NM_019841 NM_001007572
RefSeq (protein) NP_062815 NP_001007573
Location (UCSC) Chr 7:
142.61 – 142.63 Mb
Chr 6:
41.65 – 41.68 Mb
PubMed search [1] [2]

Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene.[1][2][3]

TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+.[4] Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consequentual hyperparathyroidism, and bone loss.[5]

This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel , TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.[6]

See also[edit]

Interactions[edit]

TRPV5 has been shown to interact with S100A10.[7]

References[edit]

  1. ^ Muller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (Sep 2000). "Gene structure and chromosomal mapping of human epithelial calcium channel". Biochem Biophys Res Commun 275 (1): 47–52. doi:10.1006/bbrc.2000.3227. PMID 10944439. 
  2. ^ Muller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI, Eggert P, Garcia-Nieto V, Claverie-Martin F, Bindels RJ (Nov 2000). "Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1)". Genomics 67 (1): 48–53. doi:10.1006/geno.2000.6203. PMID 10945469. 
  3. ^ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol Rev 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  4. ^ Hoenderop,J.G.; Nilius,B.; Bindels,R.J. (2002). "Molecular mechanism of active Ca2+ reabsorption in the distal nephron". Annu. Rev Physiol. 64: 529–49. doi:10.1146/annurev.physiol.64.081501.155921. PMID 11826278. 
  5. ^ Hoenderop,J.G.; van Leeuwen,J.P.; van der Eerden,B.C.; Kersten,F.F.; van der Kemp,A.W.; Merillat,A.M.; Waarsing,J.H.; Rossier,B.C.; Vallon,V.; Hummler,E.; Bindels,R.J. (2003). "Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5". J.Clin.Invest 112 (12): 1906–14. doi:10.1172/JCI19826. PMC 297001. PMID 14679186. 
  6. ^ "Entrez Gene: TRPV5 transient receptor potential cation channel, subfamily V, member 5". 
  7. ^ van de Graaf, Stan F J; Hoenderop Joost G J, Gkika Dimitra, Lamers Dennis, Prenen Jean, Rescher Ursula, Gerke Volker, Staub Olivier, Nilius Bernd, Bindels René J M (Apr 2003). "Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10–annexin 2 complex". EMBO J. (England) 22 (7): 1478–87. doi:10.1093/emboj/cdg162. ISSN 0261-4189. PMC 152906. PMID 12660155. 

Further reading[edit]

  • Vennekens R, Droogmans G, Nilius B (2002). "Functional properties of the epithelial Ca2+ channel, ECaC". Gen. Physiol. Biophys. 20 (3): 239–53. PMID 11765215. 
  • Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes". Cell Calcium 33 (5–6): 533–40. doi:10.1016/S0143-4160(03)00058-7. PMID 12765698. 
  • Nijenhuis T, Hoenderop JG, Bindels RJ (2006). "TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate". Pflugers Arch. 451 (1): 181–92. doi:10.1007/s00424-005-1430-6. PMID 16044309. 
  • Mensenkamp AR, Hoenderop JG, Bindels RJ (2007). "TRPV5, the gateway to Ca2+ homeostasis". Handb Exp Pharmacol. Handbook of Experimental Pharmacology 179 (179): 207–20. doi:10.1007/978-3-540-34891-7_12. ISBN 978-3-540-34889-4. PMID 17217059. 
  • Schoeber JP, Hoenderop JG, Bindels RJ (2007). "Concerted action of associated proteins in the regulation of TRPV5 and TRPV6". Biochem. Soc. Trans. 35 (Pt 1): 115–9. doi:10.1042/BST0350115. PMID 17233615. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.