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TRNA splicing endonuclease 2 homolog (S. cerevisiae)
Symbols TSEN2 ; PCH2B; SEN2; SEN2L
External IDs OMIM608753 MGI2141599 HomoloGene41622 GeneCards: TSEN2 Gene
EC number
RNA expression pattern
PBB GE TSEN2 219581 at tn.png
More reference expression data
Species Human Mouse
Entrez 80746 381802
Ensembl ENSG00000154743 ENSMUSG00000042389
UniProt Q8NCE0 Q6P7W5
RefSeq (mRNA) NM_001145392 NM_199033
RefSeq (protein) NP_001138864 NP_950198
Location (UCSC) Chr 3:
12.53 – 12.58 Mb
Chr 6:
115.54 – 115.58 Mb
PubMed search [1] [2]

tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.[1][2]

tRNA splicing is a fundamental process required for cell growth and division. SEN2 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][2]


TSEN2 has been shown to interact with TSEN34[1] and C1orf19.[1]


  1. ^ a b c Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. 
  2. ^ a b "Entrez Gene: TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae)". 

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