TSPAN8

Tetraspanin 8
Identifiers
Symbols	TSPAN8; CO-029; TM4SF3
External IDs	OMIM: 600769 MGI: 2384918 HomoloGene: 20968 GeneCards: TSPAN8 Gene
Gene Ontology Molecular function • signal transducer activity Cellular component • lysosome • membrane • integral to membrane Biological process • protein glycosylation • signal transduction • negative regulation of blood coagulation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7103	216350
Ensembl	ENSG00000127324	ENSMUSG00000034127
UniProt	P19075	Q8R3G9
RefSeq (mRNA)	NM_004616.2	NM_001168679.1
RefSeq (protein)	NP_004607.1	NP_001162150.1
Location (UCSC)	Chr 12: 71.52 – 71.84 Mb	Chr 10: 115.25 – 115.29 Mb
PubMed search	[1]	[2]

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.

Further reading

• Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Gwynn B, Eicher EM, Peters LL (1996). "Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome". Genomics 35 (2): 389–91. doi:10.1006/geno.1996.0375. PMID 8661157. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (Pt 1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220227. 
• Kanetaka K, Sakamoto M, Yamamoto Y, et al. (2002). "Overexpression of tetraspanin CO-029 in hepatocellular carcinoma". J. Hepatol. 35 (5): 637–42. doi:10.1016/S0168-8278(01)00183-0. PMID 11690710. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Shackel NA, McGuinness PH, Abbott CA, et al. (2003). "Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization". Hepatology 38 (3): 577–88. doi:10.1053/jhep.2003.50376. PMID 12939584. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Kuhn S, Koch M, Nübel T, et al. (2007). "A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression". Mol. Cancer Res. 5 (6): 553–67. doi:10.1158/1541-7786.MCR-06-0384. PMID 17579117.