TSPAN8

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Tetraspanin 8
Identifiers
Symbols TSPAN8 ; CO-029; TM4SF3
External IDs OMIM600769 MGI2384918 HomoloGene20968 GeneCards: TSPAN8 Gene
RNA expression pattern
PBB GE TSPAN8 203824 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7103 216350
Ensembl ENSG00000127324 ENSMUSG00000034127
UniProt P19075 Q8R3G9
RefSeq (mRNA) NM_004616 NM_001168679
RefSeq (protein) NP_004607 NP_001162150
Location (UCSC) Chr 12:
71.52 – 71.84 Mb
Chr 10:
115.82 – 115.85 Mb
PubMed search [1] [2]

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.[2]

References[edit]

  1. ^ Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (Oct 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proc Natl Acad Sci U S A 87 (17): 6833–7. doi:10.1073/pnas.87.17.6833. PMC 54632. PMID 2395876. 
  2. ^ a b "Entrez Gene: TSPAN8 tetraspanin 8". 

Further reading[edit]