TSPY1

Testis specific protein, Y-linked 1
Identifiers
Symbols	TSPY1; CT78; DYS14; TSPY; pJA923
External IDs	OMIM: 480100 HomoloGene: 87844 GeneCards: TSPY1 Gene
Gene Ontology Molecular function • molecular_function • protein binding • identical protein binding Cellular component • cellular_component • nucleus • cytoplasm Biological process • nucleosome assembly • multicellular organismal development • spermatogenesis • gonadal mesoderm development • sex differentiation • cell proliferation • cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7258	n/a
Ensembl	ENSG00000168757	n/a
UniProt	Q01534	n/a
RefSeq (mRNA)	NM_001197242.1	n/a
RefSeq (protein)	NP_001184171.1	n/a
Location (UCSC)	Chr Y: 6.17 – 6.18 Mb	n/a
PubMed search	[1]	n/a

Testis-specific Y-encoded protein 1 is a protein that in humans is encoded by the TSPY1 gene.

Further reading

• Chandley AC, Cooke HJ (1995). "Human male fertility--Y-linked genes and spermatogenesis.". Hum. Mol. Genet.. 3 Spec No: 1449–52. PMID 7849736. 
• Vogel T, Schmidtke J (1998). "Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein".". Cytogenet. Cell Genet. 80 (1-4): 209–13. doi:10.1159/000014982. PMID 9678360. 
• Lau YF (2000). "Gonadoblastoma, testicular and prostate cancers, and the TSPY gene.". Am. J. Hum. Genet. 64 (4): 921–7. doi:10.1086/302353. PMC 1377814. PMID 10090875. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1377814. 
• Zhang JS, Yang-Feng TL, Muller U, et al. (1993). "Molecular isolation and characterization of an expressed gene from the human Y chromosome.". Hum. Mol. Genet. 1 (9): 717–26. doi:10.1093/hmg/1.9.717. PMID 1284595. 
• Arnemann J, Jakubiczka S, Thüring S, Schmidtke J (1992). "Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY.". Genomics 11 (1): 108–14. doi:10.1016/0888-7543(91)90107-P. PMID 1765369. 
• Arnemann J, Epplen JT, Cooke HJ, et al. (1988). "A human Y-chromosomal DNA sequence expressed in testicular tissue.". Nucleic Acids Res. 15 (21): 8713–24. doi:10.1093/nar/15.21.8713. PMC 306400. PMID 3479749. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=306400. 
• Manz E, Schnieders F, Brechlin AM, Schmidtke J (1993). "TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome.". Genomics 17 (3): 726–31. doi:10.1006/geno.1993.1393. PMID 8244388. 
• Kim HS, Takenaka O (1996). "A comparison of TSPY genes from Y-chromosomal DNA of the great apes and humans: sequence, evolution, and phylogeny.". Am. J. Phys. Anthropol. 100 (3): 301–9. doi:10.1002/(SICI)1096-8644(199607)100:3<301::AID-AJPA1>3.0.CO;2-X. PMID 8798990. 
• Schnieders F, Dörk T, Arnemann J, et al. (1997). "Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues.". Hum. Mol. Genet. 5 (11): 1801–7. doi:10.1093/hmg/5.11.1801. PMID 8923009. 
• Vogt PH, Affara N, Davey P, et al. (1998). "Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997.". Cytogenet. Cell Genet. 79 (1-2): 1–20. doi:10.1159/000134680. PMID 9533010. 
• Vogel T, Dittrich O, Mehraein Y, et al. (1998). "Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family.". Cytogenet. Cell Genet. 81 (3-4): 265–70. doi:10.1159/000015042. PMID 9730615. 
• Lau YF, Zhang J (2000). "Expression analysis of thirty one Y chromosome genes in human prostate cancer.". Mol. Carcinog. 27 (4): 308–21. doi:10.1002/(SICI)1098-2744(200004)27:4<308::AID-MC9>3.0.CO;2-R. PMID 10747295. 
• Ratti A, Stuppia L, Gatta V, et al. (2000). "Characterization of a new TSPY gene family member in Yq (TSPYq1).". Cytogenet. Cell Genet. 88 (1-2): 159–62. doi:10.1159/000015510. PMID 10773691. 
• Dechend F, Williams G, Skawran B, et al. (2001). "TSPY variants in six loci on the human Y chromosome.". Cytogenet. Cell Genet. 91 (1-4): 67–71. doi:10.1159/000056821. PMID 11173833. 
• Lau Y, Chou P, Iezzoni J, et al. (2001). "Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma.". Cytogenet. Cell Genet. 91 (1-4): 160–4. doi:10.1159/000056838. PMID 11173850. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Krick R, Jakubiczka S, Arnemann J (2003). "Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes.". Gene 302 (1-2): 11–9. doi:10.1016/S0378-1119(02)01104-6. PMID 12527192.