TST (gene)

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Thiosulfate sulfurtransferase (rhodanese)
Protein TST PDB 1dp2.png
PDB rendering based on 1dp2.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TST ; RDS
External IDs OMIM180370 MGI98852 HomoloGene37759 GeneCards: TST Gene
EC number 2.8.1.1
RNA expression pattern
PBB GE TST 209605 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7263 22117
Ensembl ENSG00000128311 ENSMUSG00000044986
UniProt Q16762 P52196
RefSeq (mRNA) NM_001270483 NM_009437
RefSeq (protein) NP_001257412 NP_033463
Location (UCSC) Chr 22:
37.41 – 37.42 Mb
Chr 15:
78.4 – 78.41 Mb
PubMed search [1] [2]

Thiosulfate sulfurtransferase is an enzyme that in humans is encoded by the TST gene.[1][2]

The product of this gene is a mitochondrial matrix enzyme that is encoded by the nucleus. It may play roles in cyanide detoxification, the formation of iron-sulfur proteins, and the modification of sulfur-containing enzymes. The gene product contains two highly conservative domains (rhodanese homology domains), suggesting these domains have a common evolutionary origin.[2]

References[edit]

  1. ^ Pallini R, Guazzi GC, Cannella C, Cacace MG (Dec 1991). "Cloning and sequence analysis of the human liver rhodanese: comparison with the bovine and chicken enzymes". Biochem Biophys Res Commun 180 (2): 887–93. doi:10.1016/S0006-291X(05)81148-9. PMID 1953758. 
  2. ^ a b "Entrez Gene: TST thiosulfate sulfurtransferase (rhodanese)". 

Further reading[edit]