TUBA1B

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Tubulin, alpha 1b
Protein TUBA1B PDB 1ffx.png
PDB rendering based on 1ffx.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TUBA1B ; K-ALPHA-1
External IDs OMIM602530 MGI107804 HomoloGene134527 GeneCards: TUBA1B Gene
RNA expression pattern
PBB GE TUBA1A 201090 x at tn.png
PBB GE TUBA1A 209251 x at tn.png
PBB GE TUBA1A 211058 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10376 22143
Ensembl ENSG00000123416 ENSMUSG00000023004
UniProt P68363 P05213
RefSeq (mRNA) NM_006082 NM_011654
RefSeq (protein) NP_006073 NP_035784
Location (UCSC) Chr 12:
49.52 – 49.53 Mb
Chr 15:
98.93 – 98.93 Mb
PubMed search [1] [2]

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.[1][2][3]


Interactions[edit]

TUBA1B has been shown to interact with PIK3R1.[4] Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.[5]

References[edit]

  1. ^ Banerjee A (Jun 2002). "Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells". Biochem Biophys Res Commun 293 (1): 598–601. doi:10.1016/S0006-291X(02)00269-3. PMID 12054644. 
  2. ^ Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (Jan 1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol Cell Biol 3 (10): 1738–45. PMC 370035. PMID 6646120. 
  3. ^ "Entrez Gene: TUBA1B tubulin, alpha 1b". 
  4. ^ Kapeller, R; Toker A; Cantley L C; Carpenter C L (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". J. Biol. Chem. (UNITED STATES) 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. ISSN 0021-9258. PMID 7592789. 
  5. ^ http://www.genetex.com/WebPage/Product/PromotionDetail.aspx?Type=Promotion&PromotionID=178

Further reading[edit]

External links[edit]