Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. Alternative splicing has been observed for this gene and two variants have been identified.
^Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J (Feb 2002). "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau". The Journal of Neuroscience : The Official Journal of the Society for Neuroscience22 (3): 698–707. PMID11826099.
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Guilford P, Dodé C, Crozet F, Blanchard S, Chaïb H, Levilliers J et al. (Sep 1995). "A YAC contig and an EST map in the pericentromeric region of chromosome 13 surrounding the loci for neurosensory nonsyndromic deafness (DFNB1 and DFNA3) and limb-girdle muscular dystrophy type 2C (LGMD2C)". Genomics29 (1): 163–9. doi:10.1006/geno.1995.1227. PMID8530067.Check date values in: |year= / |date= mismatch (help)
Marie-Cardine A, Kirchgessner H, Eckerskorn C, Meuer SC, Schraven B (Dec 1995). "Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase". European Journal of Immunology25 (12): 3290–7. doi:10.1002/eji.1830251214. PMID8566014.Check date values in: |year= / |date= mismatch (help)
Kibar Z, Lafrenière RG, Chakravarti A, Wang JC, Chevrette M, Der Kaloustian VM et al. (Feb 1999). "A radiation hybrid map of 48 loci including the clouston hidrotic ectodermal dysplasia locus in the pericentromeric region of chromosome 13q". Genomics56 (1): 127–30. doi:10.1006/geno.1998.5698. PMID10036193.CS1 maint: Date and year (link)
Herreros L, Rodríguez-Fernandez JL, Brown MC, Alonso-Lebrero JL, Cabañas C, Sánchez-Madrid F et al. (Aug 2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton". The Journal of Biological Chemistry275 (34): 26436–40. doi:10.1074/jbc.M003970200. PMID10840040.CS1 maint: Date and year (link)
Takeoka A, Shimizu M, Horio T (Dec 2000). "Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction". Journal of Cell Science. 113 Pt 24: 4557–62. PMID11082048.Check date values in: |year= / |date= mismatch (help)
Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (Dec 2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID11146551.Check date values in: |year= / |date= mismatch (help)
Kourmouli N, Dialynas G, Petraki C, Pyrpasopoulou A, Singh PB, Georgatos SD et al. (Apr 2001). "Binding of heterochromatin protein 1 to the nuclear envelope is regulated by a soluble form of tubulin". The Journal of Biological Chemistry276 (16): 13007–14. doi:10.1074/jbc.M007135200. PMID11278332.CS1 maint: Date and year (link)
Rommelaere H, De Neve M, Neirynck K, Peelaers D, Waterschoot D, Goethals M et al. (Nov 2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families". The Journal of Biological Chemistry276 (44): 41023–8. doi:10.1074/jbc.M106591200. PMID11535601.CS1 maint: Date and year (link)
Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J (Feb 2002). "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau". The Journal of Neuroscience : The Official Journal of the Society for Neuroscience22 (3): 698–707. PMID11826099.CS1 maint: Date and year (link)