Alpha-tubulin 3C

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Tubulin, alpha 3c
Protein TUBA3C PDB 1ffx.png
PDB rendering based on 1ffx.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TUBA3C ; TUBA2; bA408E5.3
External IDs OMIM602528 MGI3647798 HomoloGene134742 GeneCards: TUBA3C Gene
Species Human Mouse
Entrez 7278 22144
Ensembl ENSG00000075886 ENSMUSG00000067338
UniProt Q13748 P05214
RefSeq (mRNA) NM_006001 NM_009446.2
RefSeq (protein) NP_005992 NP_033472.1
Location (UCSC) Chr 13:
19.75 – 19.76 Mb
Chr 6:
125.23 – 125.24 Mb
PubMed search [1] [2]

Tubulin alpha-3C/D chain is a protein that in humans is encoded by the TUBA3C gene.[1][2]

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. Alternative splicing has been observed for this gene and two variants have been identified.[2]


Alpha-tubulin 3C has been shown to interact with FYN[3] and NMI.[4]


  1. ^ Dode C, Weil D, Levilliers J, Crozet F, Chaib H, Levi-Acobas F, Guilford P, Petit C (April 1998). "Sequence characterization of a newly identified human alpha-tubulin gene (TUBA2)". Genomics 47 (1): 125–30. doi:10.1006/geno.1997.5081. PMID 9465305. 
  2. ^ a b "Entrez Gene: TUBA3C tubulin, alpha 3c". 
  3. ^ Klein, Corinna; Kramer Eva-Maria; Cardine Anne-Marie; Schraven Burkhardt; Brandt Roland; Trotter Jacqueline (February 2002). "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau". J. Neurosci. (United States) 22 (3): 698–707. PMID 11826099. 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

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