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Twist family bHLH transcription factor 2
External IDs OMIM607556 HomoloGene40594 GeneCards: TWIST2 Gene
Species Human Mouse
Entrez 117581 13345
Ensembl ENSG00000233608 ENSMUSG00000007805
UniProt Q8WVJ9 Q9D030
RefSeq (mRNA) NM_001271893 NM_007855
RefSeq (protein) NP_001258822 NP_031881
Location (UCSC) Chr 2:
239.76 – 239.8 Mb
Chr 1:
91.8 – 91.85 Mb
PubMed search [1] [2]

Twist-related protein 2 is a protein that in humans is encoded by the TWIST2 gene.[1][2][3]

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype.[3]


TWIST2 has been shown to interact with SREBF1.[4]


  1. ^ Li L, Cserjesi P, Olson EN (Dec 1995). "Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis". Dev Biol 172 (1): 280–92. doi:10.1006/dbio.1995.0023. PMID 7589808. 
  2. ^ Perrin-Schmitt F, Bolcato-Bellemin AL, Bourgeois P, Stoetzel C, Danse JM (Apr 1997). "The locations of the H-twist and H-dermo-1 genes are distinct on the human genome". Biochim Biophys Acta 1360 (1): 1–2. doi:10.1016/s0925-4439(96)00071-3. PMID 9061034. 
  3. ^ a b "Entrez Gene: TWIST2 twist homolog 2 (Drosophila)". 
  4. ^ Lee, Yun Sok; Lee Hyoung Ho; Park Jiyoung; Yoo Eung Jae; Glackin Carlotta A; Choi Young Il; Jeon Sung Ho; Seong Rho Hyun; Park Sang Dai; Kim Jae Bum (Dec 2003). "Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c". Nucleic Acids Res. (England) 31 (24): 7165–74. doi:10.1093/nar/gkg934. PMC 291873. PMID 14654692. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.