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Thioredoxin 2
Protein TXN2 PDB 1uvz.png
PDB rendering based on 1uvz.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TXN2 ; MT-TRX; MTRX; TRX2
External IDs OMIM609063 MGI1929468 HomoloGene40849 GeneCards: TXN2 Gene
RNA expression pattern
PBB GE TXN2 209077 at tn.png
PBB GE TXN2 209078 s at tn.png
More reference expression data
Species Human Mouse
Entrez 25828 56551
Ensembl ENSG00000100348 ENSMUSG00000005354
UniProt Q99757 P97493
RefSeq (mRNA) NM_012473 NM_019913
RefSeq (protein) NP_036605 NP_064297
Location (UCSC) Chr 22:
36.86 – 36.88 Mb
Chr 15:
77.92 – 77.93 Mb
PubMed search [1] [2]

Thioredoxin, mitochondrial also known as thioredoxin-2 is a protein that in humans is encoded by the TXN2 gene.[1][2][3]


This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.[3]


  1. ^ Spyrou G, Enmark E, Miranda-Vizuete A, Gustafsson J (Mar 1997). "Cloning and expression of a novel mammalian thioredoxin". J Biol Chem 272 (5): 2936–41. doi:10.1074/jbc.272.5.2936. PMID 9006939. 
  2. ^ Zhou J, Damdimopoulos AE, Spyrou G, Brune B (Mar 2007). "Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha". J Biol Chem 282 (10): 7482–90. doi:10.1074/jbc.M608289200. PMID 17220299. 
  3. ^ a b "Entrez Gene: TXN2 thioredoxin 2". 

Further reading[edit]