On July 15, an undisclosed injury forced Andre Galvao out of his fight with Jorge Lopez.Strikeforce veteran David Marshall stepped in as Galvao's replacement.
TPF middleweight champion David Loiseau was originally slated to face Giva Santana, but had to pull out of the fight due to an undisclosed injury requiring surgery. Former WEC champion Doug Marshall took his place. He faced Santana in a middleweight non-title bout. The event was notable in that the free live stream provided on Sherdog.com was of unusually low quality, freezing for minutes at a time. As a result of this, a meme has started, dubbing TPF 10 as "Let the Stream Fail", rather than the events actual name,"Let the Chips Fall".