Talarozole

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Talarozole
Talarozole skeletal.svg
Systematic (IUPAC) name
N-(2-Benzothioazolyl)-N-[4-[2-ethyl-1-(1,2,4-triazo-1-yl)butyl]phenyl]amine
Clinical data
Legal status ?
Routes oral, topical
Identifiers
CAS number 201410-53-9 YesY
ATC code None
PubChem CID 9799888
ChemSpider 7975653 N
UNII XKD9N5CJ6W YesY
Chemical data
Formula C21H23N5S 
Mol. mass 377.505 g/mol
 N (what is this?)  (verify)

Talarozole (formerly R115866, planned trade name Rambazole) is an investigational drug for the treatment of acne, psoriasis and other keratinization disorders.

Talarozole inhibits the metabolism of retinoic acid by blocking the cytochrome P450 enzyme isoform CYP26, a retinoic acid hydroxylase. Because of this mechanism, it is called a retinoic acid metabolism blocking agent (RAMBA).[1]

References[edit]

  1. ^ Giltaire, S; Herphelin F; Frankart A; Hérin M; Stoppie P; Poumay Y (11 December 2008). "The CYP26 inhibitor R115866 potentiates the effects of all-trans retinoic acid on cultured human epidermal keratinocytes". Br J Dermatol 160 (3): 505–13. doi:10.1111/j.1365-2133.2008.08960.x. PMID 19120344.