Talbutal

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Talbutal
Talbutal.svg
Systematic (IUPAC) name
(RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione
Clinical data
Legal status
Identifiers
CAS number 115-44-6 YesY
ATC code N05CA07
PubChem CID 8275
DrugBank DB00306
ChemSpider 7976 YesY
UNII 4YIR8202AX YesY
ChEMBL CHEMBL1200802 N
Synonyms 5-(1-methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Chemical data
Formula C11H16N2O3 
Mol. mass 224.256 g/mol
 N (what is this?)  (verify)

Talbutal (Lotusate) is a barbiturate with a short to intermediate duration of action. It is a structural isomer of butalbital. Talbutal is a schedule III drug in the U.S.

Pharmacology[edit]

Talbutal is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.[1]

Mechanism of action[edit]

Talbutal binds at a distinct binding site associated with a Cl ionopore at the GABAA receptor, increasing the duration of time for which the Cl ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Toxicity[edit]

Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension,[1] and shock.

References[edit]

  1. ^ a b Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 280ff. ISBN 3-8047-1763-2.