Talk:Paracrine signalling
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As this article reads ("a form of signalling in which the target cell is close to the signal releasing cell"), the neural synapse would be a form of paracrine signalling. Is this this case? If so, it should probably be mentioned because it's so important; if not, then it should be specifically excluded.
- Well, neurotransmission could be classified as such, except nobody does so. JFW | T@lk 15:38, 11 January 2006 (UTC)
Also neurotransmission and paracrine signalling is differentiated by the time course and molecular arrangement of the transmission. Therefore while the target cell and releasing cell are relatively proximal in both, the biological nature of the two transmissions are quite discernible. SteveD. —Preceding unsigned comment added by 58.166.82.170 (talk) 23:43, 14 March 2008 (UTC)
[edit] Autocrine
The introduction to this article says that autocrine signaling is signaling to other cells of the same type. The Autocrine signalling, on the other hand, says that it's to the same cell, and the definition at Dictionary.com appears to agree with this latter definition. Is the definition given in this article accurate but broader? An out-of-date usage? Just simply incorrect? A correction and/or clarification appears to be in order, but I am not familiar enough with the subject to make the necessary changes. --Icarus (Hi!) 00:33, 21 May 2008 (UTC)
I agree with Icarus. Autocrine signaling, as commonly used and as defined in the standard textbook Molecular biology of the cell, is the process of cells "sending signals to themselves". Clearly that signal can also be received by other identical cells, and indeed this is a thought to be a mechanism for differentiation or a 'community effect' where groups of cells respond to a signal better than an isolated cell. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=autocrine&rid=cell.section.3835#3843
Perhaps the introduction can be revised to ' Both affect neighboring cells, but whereas autocrine signaling affects the signal-producing cell and identical cells, paracrine signaling affects cells different from the signaling cell.' CG (talk) 06:15, 10 September 2008 (UTC)
Autocrine factors are secreted or cell surface bound growth factors and cytokines that are expressed by a cell to act on itself or adjacent cells of the same lineage. The emphasis is on the same cell lineage. Therefore this means the same cell type. If the target of action is on adjacent cells of different lineage then it is regarded as juxtacrine actioning. SteveD 13th June 2010 08:24 a.m. —Preceding unsigned comment added by 220.239.124.4 (talk) 22:24, 12 June 2010 (UTC)
