Talk:Tetracycline

Chemical structure of tetracycline. The name is obviously derived from the structure of the molecule.

Oh, well, obviously. I mean, duh, this is so self-explanatory I don't know why it's even on the page. What, do we have to spell it out for people? Garrett Albright 04:39, 8 Mar 2005 (UTC)

Umm I'm not so sure I should change this page, given my lack of knowledge, but this page is meant to be on the tetracyclic antidepressant group, NOT the antibiotic tetracycline who's name is clocely related. Totally different.

• Tetracyclines now redirects to Tetracycline antibiotics that discusses the group in general. This leaves Tetracycline to consider this specific member of the group. David Ruben ^Talk 01:36, 20 February 2006 (UTC)

sorry does anyone know the pka of this molecule and whether it is an acid or a base

Posted 01:26, 15 March 2006 by 84.9.116.2

yes the pka is 390 and it is a base pH12 —Preceding unsigned comment added by 78.148.50.47 (talk) 18:30, 28 January 2008 (UTC)

invalid link to uspto.gov

The link to uspto.gov leads to 'MACHINE FOR CLEANING OIL COOLER RADIATORS, ETC'; which has nothing to do with tetracycline 69.95.236.244 (talk) 02:25, 7 March 2008 (UTC)

Thank you. Fixed. You still won't be able to read the patent at the USPTO, because it's too old to be stored in text form; but the PDF link will work. TJRC (talk) 02:32, 7 March 2008 (UTC)

things i want to know about the drug

Please,can this drug be use for the cure gonorrhea infection? —Preceding unsigned comment added by 41.210.24.80 (talk) 16:43, 12 July 2009 (UTC)

The brand name Terramycin (instead of tetracycline) was long ago used in STD cases. Don't know if the article should specify which names doctors preferred for treating different types of problems for which tetracycline was effective. This is affected by drug companies using promotional enticements (to doctors) for prescribing certain brand names of tetracycline for treatment. One of my dermatologists earned a trip to Hawaii for prescribing a large number of a specific brand of botox.AnimeJanai (talk) 02:55, 26 June 2011 (UTC)

Don't know, but it can be used for indefinite lengths on the things it does work for and in people who don't have allergic reactions. The -cillins and mycins tend to be used most for STD bacterial infections. The cyclines prescribed seem often prescribed for lysteria or acne. Maybe someone else can answer that? I'm worried about hearing loss if I go on it. Looking for info. -Reticuli 66.178.144.102 (talk) 21:14, 23 April 2011 (UTC)

"Minocycline is the only member in this class that can cause ototoxicity, used mainly for sexually transmitted diseases such as syphilis and gonorrhea. The ototoxic effect is transient. Signs & symptoms occur early, after one or two doses, and are gone one or two days after stopping the medication." http://www.wong.ro/oto/shingvl.html Looks like that answers both of our questions. -Reticuli 66.178.144.102 (talk) 22:20, 23 April 2011 (UTC)

Aquarium Usage

Tetracycline has long been used to treat bacterial infections in fish tanks. I think it's safe to say that it's been largely replaced by kanamycin as the front-line, broad-spectrum antibiotic - probably due to the fact that it's much easier to kill fish with tetracycline - but it still sees use by people who know it well, and by people with problems that kanamycin won't solve. I keep fish myself, and I'm treating a tank with tetracycline now. I'm not familiar with any good sources that specifically mention tetracycline, but if anyone else is, I think its use on fish and some information about the procedure would merit inclusion in the article. Stagyar Zil Doggo (talk) 22:27, 26 April 2010 (UTC)

Toxic when expired

I remember reading that Tetracycline is fairly unique among medicines in that it actually becomes toxic (rather than simply less effective) if used after its expiration date. Should be useful to add to the article. (a quick google search shows this may actually be a contested claim as well, and that it may not be harmful to the kidneys) Scott Ritchie (talk) 13:20, 9 August 2010 (UTC)

IUPAC Name

Some of the IUPAC names listened cannot be true. The stereocenters have to be listened in the name. So the name: (4S,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide could be the only right one. If you confirm, delete the other ones listened. Personally I prefer the one listened on German page: (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carbamide

(Qusai80 (talk) 06:54, 9 May 2011 (UTC))

How Beer Saved The World

Armelagos (Egyptologist) found traces of tetracycline (in mummified bone) almost 3000 years prior to Alexander Fleming's discovery of Penicillin.

References: 1. Discovery Channel Documentary, How Beer Saved The World min15. 2. http://www.sciencedaily.com/releases/2010/09/100902094246.htm 3. http://www.livescience.com/11028-ancient-african-cocktail-beer-shot-antibiotic.html — Preceding unsigned comment added by Avkrules (talk • contribs) 20:48, 20 December 2011 (UTC)