|WikiProject Chemicals||(Rated B-class, High-importance)|
|WikiProject Pharmacology||(Rated Start-class, Low-importance)|
Calling it illicit is not neutral. Is it illegal? No. Do you call alcohol an illicit drug? No.
- In some states in the US, possession of 1,4-butanediol is a felony. But you're right, in a sense, because simply calling it illicit is imprecise. The article should specify where it is illegal. Edgar181 18:00, 10 March 2006 (UTC)
I'm having a bit of concern about references such as http://leda.lycaeum.org/?ID=15209 http://www.erowid.org/experiences/exp.php?ID=13226 with regard to WP:RS. Should such references be removed? --Rifleman 82 03:39, 3 July 2007 (UTC)
- leda.lycaeum.org gives me server errors, so I can't tell. The other one is certainly not a good example of a reliable source, according to Wikipedia policies. --Itub 08:30, 3 July 2007 (UTC)
I have a major issue with the following two sentences and cited sources:
"Anecdotal reports indicate that 1,4-butanediol produces a strong toxic feeling not present with GHB when ingested. These reports also indicate that it may cause damage to the liver as well as to other vital organs."
In two of the three anecdotal reports, the users attested to using 1,4-butanediol daily for weeks or months; one of them also admitted to heavy alcohol use on the weekends. The third anecdotal report involved using 5-MeO-DiPT and 1,4-butanediol in combination, and the negative side effects therefore may have been due to an interaction between the drugs.
Hello - I work for Genomatica. I wanted to provide a few clarifying points to the entry information on Genomatica under the Synthesis section of the 1,4-Butanediol page. Genomatica named its cofounder, Christophe Schilling, as its CEO in early 2009. 
The company has plans to break ground on its bio-based chemical demonstration plant for BDO in 2010.  Initial life cycle analysis (LCA) studies based on the [Greet Model] illustrate fossil energy consumption of about 17,000 BTUs/lb of BDO which is approximately a 60% reduction compared to the traditional petrochemical process The BTUs are substantially lower if bagasse is burned for energy .
Poor sources remain
I still have major issue with the following two statements:
Anecdotal reports indicate that 1,4-butanediol produces a strong toxic feeling not present with GHB when ingested. These reports also indicate that it may cause damage to the liver as well as to other vital organs.
The first report involved ingesting 1,4-butanediol together with 5-Meo-DiPT, a powerful hallucinogen. Therefore, all that report really indicates is that taking 1,4-butanediol and 5-Meo-DiPT together is not a good idea.
The second report involved a user who acknowledged taking 2-5 grams of 1,4-butanediol daily for 3 weeks. The user also acknowledged being a daily steroid user for 8 years and having had problems with his liver previously. It seems more likely that the user aggravated whatever liver problems he already had from previous drug use and/or a preexisting condition.
Here's one reliable source I was able to find on 1,4-butanediol toxicity:
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