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iochemically inaccurate - the Aciclo-GTP form is an inhibitor because it is incorporated into nascent DNA resulting in chain termination. SOMETIMES w hile the residue incorporated will be the GM--188.8.131.52 (talk) 03:44, 24 March 2013 (UTC)P form, it is the GTP form that will be the substrate for the reaction (to drive it forward through pyrophosphate release). Cheers! --184.108.40.206 12:40, 30 April 2007 (UTC)
Great page, guys. Can we move it to the INN aciclovir and have acyclovir redirect there?
Drugs of this class are also
Needs a structure image
- The image was removed by someone who probably thought "aciclovir" was a misspelling :P Fvasconcellos (t·c) 22:11, 26 January 2008 (UTC)
? positive urine drug screens
is acyclovir's inhibitory action through impairment of thymidylate kinase and acts as a competitive inhibitor of normal triphosphate nucleotides thus, can someone clear this up for me? —Preceding unsigned comment added by 220.127.116.11 (talk) 17:21, 31 May 2009 (UTC)
"Since acyclovir can also be incorporated into cellular DNA, it is a chromosome mutagen, therefore, its use should be avoided during pregnancy". I don't think this is correct. I happen to know that physicians do prescribe aciclovir during pregnancy because an herpes infection can be lethal to the newborn child. Also, aciclovir has a pregnancy category B3 (Au), B (VS) which means it's relatively safe. —Preceding unsigned comment added by 18.104.22.168 (talk) 15:00, 8 October 2009 (UTC)
- http://www.ncbi.nlm.nih.gov/pubmed/8308511 http://www.cdc.gov/mmwr/preview/mmwrhtml/00022071.htm http://pregnancyregistry.gsk.com/acyclovir.html - seems to be effectively the case that it's fine if the benefits outweigh the risks and there isn't much (if any) real evidence of risk even in very high doses. Maybe somebody should fix that. --Streaky (talk) 01:08, 8 June 2012 (UTC)
Please make molecule picture orientation similar to guanine.
This chemical is a guanine analogue, and acts like guanine with some bio-molecules, thus it's action in repressing the virus. It would assist visualizing the structure of both, if the orientation were presented with the same as that presented for guanine in this encyclopedia. Please just flip it around so the hex and penta sections can be superimposed on the guanine representations. This would more clearly indicate the distinctions as well as the similarities between the molecules.