Talk:Acute lymphoblastic leukemia

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Thanks[edit]

Thanks to User:EC, this page took off. I have taken some time to copyedit it, as there was a lot of redundancy (e.g. the side-effects of chemotherapy are general enough to go under chemotherapy and not here). Nevertheless, this is a very good article. JFW | T@lk 11:48, 25 Jul 2004 (UTC)

leukemia[edit]

leukemia is very scary to have


"For patients, like in other cancers, the success rate is either 100% or zero, rendering overall statistical rates meaningless."

To me this sounds like an inspirational speech and doesn't really have a place in an encyclopedia article. There are overall statistical rates, and they are not meaningless.

Thrombosis[edit]

doi:10.1111/j.1365-2141.2007.06677.x - ALL patients are relatively prone to thrombosis. This study looks into why and whether preventative treatment is needed. JFW | T@lk 23:13, 2 July 2007 (UTC)

Oh God![edit]

Will somebody PLEASE clean up the little summary thing before the table of contents? Dancanm 19:17, 11 July 2007 (UTC)

ALL mutation?[edit]

My cousin had ALL. In early October she went to the doctor and they found some cells they had never seen before. Doctors said ALL does not mutate, but for an unknown reason - hers had. Does ALL mutate into other forms of leukemia? Look at the October 9th and Oct. 15th entry of the link provided. Documentation of cell mutation San Antonio Guytalk 01:15, 20 December 2007 (UTC)

ALL abbreviation[edit]

I'm not convinced how useful this abbreviation is, as it could be slightly confused as 'All' with certain readers. E.g. "Initial symptoms are not specific to ALL". CycloneNimrod (talk) 17:36, 5 January 2008 (UTC

See also[edit]

I have edited this with Maarten van der Weijden. He was diagnosed with ALL in 2001. He won a gold medal in the 2008 Summer Olympics. Because I derive hope from this I wanted to share this with the community! If anyone takes offense or grief, please remove the reference!!!!!! —Preceding unsigned comment added by Paul Soomers (talkcontribs) 19:48, 26 August 2008 (UTC)

External links[edit]

I marked the ACOR link as being dead because I can't get it to open. "Server not responding." Can someone else try again, maybe tomorrow?

Additionally, Wikipedia's external links policy and the specific guidelines for medicine-related articles do not permit the inclusion of external links to non-encyclopedic material, particularly including internet chat boards and e-mail discussion groups. Because I realize that most normal editors haven't spent much time with these policies, please let me provide specific information from the guidelines:

  • This page, which applies to all articles in the entire encyclopedia, says that links "to social networking sites (such as MySpace or Fan sites), discussion forums/groups (such as Yahoo! Groups), USENET newsgroups or e-mail lists" are to be avoided.
  • This page deprecates ""helpful" external links, such as forums, self-help groups and local charities."
  • This medical-specific page reinforces the pan-Wiki rules, with a note that "All links must meet Wikipedia's external links guidelines, which in particular exclude discussion forums."

Wikipedia is an encyclopedia, and while it may occasionally be useful to patients or their families, it is not an advertising opportunity for support groups. So if this ACOR link takes us to a page that has no content, it needs to be deleted entirely, even if it starts working again. If it leads to a page with information about ALL, then that's great.

Any editor, BTW, is welcome to read all of the rules and perform an "audit" in the remaining links. Thanks, WhatamIdoing (talk) 21:28, 16 April 2008 (UTC)

Fluorescent lights contribute to ALL?[edit]

Not suitable for the article, but this is a somewhat curious study. Picked it up from a correspondence while browsing NEJM. II | (t - c) 20:50, 13 July 2008 (UTC)

Usually, the "fluorescent lights cause cancer" story is attributed to people staying inside (lack of sunshine) or staying up late at night (disrupted light/dark cycles). There's no good data on the subject, just weak speculation. WhatamIdoing (talk) 17:50, 14 July 2008 (UTC)

Secondary ALL[edit]

I'm not sure about this edit, but it seems unlikely to be correct. Once you have ALL, you can't get ALL as a secondary malignancy. But perhaps it's supposed to refer to getting ALL secondary to something else (e.g., treatment for a solid tumor)? Does anyone have a source that settles this one way or the other? WhatamIdoing (talk) 02:36, 11 January 2009 (UTC)

Patients can acquire secondary myelodysplastic syndrome which can progress to secondary acute myeloid leukemia (AML) as a result from previous exposure to certain chemotherapy drugs such as etoposide or cyclophasphamide. This is rarely seen in patients with a history of breast cancer treatment or lymphoma treatment. Even more rare is the acquisition of secondary ALL (sALL) as a result from similar circumstances. There are several case reports and case series which report on secondary ALL. —Preceding unsigned comment added by Apconley2004 (talkcontribs) 19:57, 23 January 2010 (UTC)

Is t(3;21)(p14;q22) relevant?[edit]

http://www.ncbi.nlm.nih.gov/pubmed/3088882 From that link: Abstract High-resolution chromosome banding studies were carried out on leukemic cells from a young patient with acute nonlymphocytic leukemia (ANLL), M2 of the FAB classification. A new chromosomal abnormality involving a translocation between chromosomes 3 and 21 was observed, i.e., t(3;21)(p14;q22). A complete remission was never obtained in spite of aggressive chemotherapy and the patient died 8 months after diagnosis. —Preceding unsigned comment added by 2.38.75.52 (talk) 11:30, 26 March 2011 (UTC)

Prognosis of t(8;14)[edit]

There is a contradiction in the 2 tables on this page. Under the heading 'Cytogenetics' it says in the table that the translocation t(8;14)(q24.1;q32) has a poor prognosis, but under 'Prognosis' another table says that rearrangements of 8q24 are intermediate. Being the father of a T-ALL patient with t(8;14) I'd be particularly interested in expert clarification. Thanks in advance. —Preceding unsigned comment added by 212.249.12.50 (talk) 13:04, 14 January 2009 (UTC)

Suggestion: Intensification = consolidation[edit]

Suggest adding consolidation in parenthesis next to intensification as they mean the same thing with regard to chemo treatment. Source: cancer.org --Ymarker (talk) 20:57, 18 January 2010 (UTC)

No hint of any current R and D[edit]

Article should summarise current R&D or refer back to leukemia ? Rod57 (talk) 19:47, 15 July 2010 (UTC)

WHO 'proposed' were adopted in 2008[edit]

The FAB material should be condensed and the newer classification expanded, including the cross-referencing to Burkitt's —Preceding unsigned comment added by 69.153.51.220 (talk) 09:32, 9 September 2010 (UTC)

'Acute'[edit]

The acute should refer to the fact that the cells does not progress pass the blast stage and not about time. — Preceding unsigned comment added by Kingdarm (talkcontribs) 05:18, 6 October 2011 (UTC)

Lancet review article[edit]

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2812%2962187-4/abstract The Lancet,
Early Online Publication, 22 March 2013
doi:10.1016/S0140-6736(12)62187-4
Acute lymphoblastic leukaemia
Dr Hiroto Inaba MD a Corresponding Author, Prof Mel Greaves PhD c, Charles G Mullighan MD b

--Nbauman (talk) 02:26, 22 March 2013 (UTC)

Immunophenotype[edit]

Can someone add the immunophenotype (like CD10+, CD20+, CD3+ etc..) of pre-B and pre-T ALL? In this moment, there are only undefinied "T, B cell associate antigen", it isn't very useful.. Thank you, although still a good article! — Preceding unsigned comment added by 130.192.119.9 (talk) 11:50, 6 May 2013 (UTC)

Review[edit]

Inaba, H; Greaves, M; Mullighan, CG (2013 Jun 1). "Acute lymphoblastic leukaemia.". Lancet 381 (9881): 1943–55. PMID 23523389.  Doc James (talk · contribs · email) (if I write on your page reply on mine) 17:36, 23 July 2013 (UTC)