Talk:Agouti-related peptide

From Wikipedia, the free encyclopedia
Jump to: navigation, search
WikiProject Medicine (Rated C-class, Low-importance)
WikiProject icon This article is within the scope of WikiProject Medicine, which recommends that this article follow the Manual of Style for medicine-related articles and use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.
C-Class article C  This article has been rated as C-Class on the project's quality scale.
 Low  This article has been rated as Low-importance on the project's importance scale.
 
WikiProject Molecular and Cellular Biology (Rated C-class, Low-importance)
WikiProject icon This article is within the scope of the WikiProject Molecular and Cellular Biology. To participate, visit the WikiProject for more information.
C-Class article C  This article has been rated as C-Class on the project's quality scale.
 Low  This article has been rated as Low-importance on the project's importance scale.
 

Comment[edit]

Why is it named after a South-American rodent?!

No idea -- what's an Agouti anyway? -- The Anome 15:29, 11 March 2006 (UTC)

Agouti is a protein found in the epidermis that binds to MC1R producing a yellow/tan fur color. Agouti Related protein (Ag R P) is structurally similar protein important in metabolism regulation that is found in the brain. AgRP is AgrP. peptide and protein are synonymous. i.e. these should be merged.

Agouti protein was named after the South-American rodent because it produces coat color similar to this rodent. In mice, agouti protein is transiently synthesized in the skin to give different coat colors during development. Certain mice however possess a mutation in the Agouti gene inducing a prolong and ectopic expression of agouti including in the brain. These animals develop obesity and diabetes by blocking melanocortin 4 receptors (Mc4r).