Talk:Angiotensin II receptor antagonist
|WikiProject Pharmacology||(Rated C-class, Top-importance)|
|WikiProject Medicine||(Rated C-class, Mid-importance)|
additional side effects
ARB's have been shown to be teratogenic. http://www.fda.gov/hearthealth/treatments/medications/arbs.html under "pregnancy" category.
22.214.171.124 21:53, 27 August 2007 (UTC)Mko
call it ARB
shouldn't this article really be changed to Angiotensin Receptor Blocker ? All the world seems to use that term.
Eprosartan has to be added (with his link); a wikipedia page of it already exists: http://en.wikipedia.org/wiki/Eprosartan
Comparison of Pharmacokinetics
The table comparing the drug pharmacokinetics needs looking at or referencing. Most of them are mostly excreted unchanged with little hepatic metabolism, or as I understand it from the MIMS database (database of drug information provided by manufacturer). The numbers aren't the wrong way around either, they're completely different.
On an additional note in regards to an earlier comment, 'Angiotensin II receptor antagonist' is the more correct term for the class of drug. 'Angiotensin receptor blocker' is a bit of a colloquialism like 'beta blocker', which should technically be 'beta-adrenergic receptor antagonist'. —Preceding unsigned comment added by 126.96.36.199 (talk) 06:28, 7 April 2011 (UTC)
This addition is troubling. The cited meta-analysis found "(7.2%vs 6.0%, risk ratio [RR] 1.08, 95% CI 1.01-1.15; p=0.016)". A difference this small in a meta-analysis is nearly lost in the experimental error even if the methodology was perfect in all the original studies. Any flaws in methodology could wipe them out. But the real problem is that it looks at one particular endpoint (cancer) while ignoring others (whether stroke, cardiac events, or even lightning strike). The relevant comparison is for all types of M&M, not just one. On a random basis over the ensemble of outcomes, some risks appear to go up while others appear to go down. We can't tell if this RR is anything more than that random effect.LeadSongDog come howl! 13:46, 2 September 2011 (UTC)
Sticky note idea
I was moving from Wikipedia article to article trying to figure out what effects the different antihypertension drugs have (just the basic types, not specific drug names) and came across "These substances are AT1-receptor antagonists; that is, they block the activation of [angiotensin II AT1 receptors.]" When I clicked the link, I was taken to a general article about all the angiotensin receptors and I had to remember that I was trying to figure out what a blocker of type 2 angiotensin would be doing to it. It's easy to lose track of what you're trying to figure out, especially in a medical series of articles, and when the articles hand you a jargon and don't explain it right there. Since I have to click through, maybe you could help me out with a handy script that pops up a sticky note saying "From angiotensin II blocker article. Sentence: These substances are AT1-receptor antagonists; that is, they block the activation of angiotensin II AT1 receptors. [Back to article]" Or put it at the top or bottom, or side of each page? That would majorly help me keep it straight. Well consider it please. Thanks. -Confused 188.8.131.52 (talk) 14:16, 5 September 2013 (UTC)