|WikiProject Medicine||(Rated B-class, Mid-importance)|
Calcium, Zinc and ATA
Eur J Intern Med. 2008 Mar;19(2):83-91. Transglutaminase and the pathogenesis of coeliac disease. Stenberg P, Roth EB, Sjöberg K.
"....With its focus on TG2, this review highlights some of the intriguing mechanisms of the pathogenesis of coeliac disease, such as the structure of the neo-antigen, the involvement of calcium and zinc, and the effects of coeliac antibodies on TG2 activity. Moreover, the many pitfalls due to dubious laboratory practice are addressed, as is the potential when a fundamental biological mechanism is understood at the molecular level...." —Preceding unsigned comment added by Pdeitiker (talk • contribs) 00:55, 16 February 2008 (UTC)
Association with multiple myeloma
BMC Immunol. 2008 May 28;9:22. Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma.Juranic Z, Radic J, Konic-Ristic A, Jelic S, Mihaljevic B, Stankovic I, Matkovic S, Besu I, Gavrilović D.
"Statistical analysis of data obtained revealed that only the levels of anti-tTG-2 IgA immunoreactivity in patients with MM were significantly higher than these obtained in healthy controls (P < 0.02) CONCLUSION: Data obtained showed the existence of the enhanced serum immunoreactivity to gliadin, tTG-2 and Ro/SSA antigens in some patients with MM. These at least partially could contribute to the immunological imbalance frequently found in this disease."
too much emphasis on celiac
this whole article is apparently done by people concerned with celiac disease. the "associated conditions" sections should have separate, clear descriptions for each associated condition associated with presence of these antibodies. NOT how these conditions relate to celiac. I will edit accordingly —Preceding unsigned comment added by Jytdog (talk • contribs) 02:27, 1 November 2010 (UTC)