Talk:Antigen-presenting cell

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Is there somebody that know, if there is rules for whis sequences are presented by APCs? If yes, can he describe it to page of Antigen-presenting cell? Thanks. Bal.

As well, there are specialized cells in particular organs (e.g., microglia in the brain, Kupffer cells in the liver), derived from macrophages that are also effective APCs.

I deleted this this because microglia, Kupffer cells, histocytes, osteoclasts, etc are just specific names for macrophages found in particular locations, and it is redundunt to mention them again. —Preceding unsigned comment added by (talk) 18:02, 16 July 2008 (UTC)

This article really needs some sources for verification —Preceding unsigned comment added by (talk) 00:52, 11 August 2010 (UTC)

Line about B cells as APC doesn't make sense[edit]

The line reads: "B-cells, which expresses (as B cell receptor) and secretes a specific antibody, can internalize the antigen which bind to its BCR and present it incorporated to MHC II molecule, but are inefficient APC for most other antigens."

This line never states what type of antigen the B is picking up, so it's conclusion that it is not an effective APC for most other antigens is confusing. Can anyone clarify this? —Preceding unsigned comment added by Mizower (talkcontribs) 01:43, 16 October 2010 (UTC)

Macrophage somewhat implied to be a T-cell?[edit]

This text, in a bullet within the Professional APCs section, is unclear:

Macrophages, which are also CD4+ cells and are therefore susceptible to infection by HIV as well, since HIV invades immune cells through CD4+ receptor interactions.

I'm studying this, and from what I've read elsewhere, macrophages aren't "CD4+ cells", but cells with exhibit the CD4 complex on their cell membrane. Since T-Helper cells are often referred to as "CD4+ T Helper cells" (e.g., in the introduction to CD4), the text as it stands can be read to imply that a macrophage is a type of T-cell. I'm not far enough along in my studies to want to correct this myself, however. — Preceding unsigned comment added by (talk) 07:28, 17 October 2014 (UTC)

  • Antigen is internalized via endocytosis
  • Antigen is digested and destroyed in the phagolysosome
  • Antigen presenting cell(A.P.C):is cell that diplays foreign antigen complexed with Major histocompatibitity complexes (M.H.C) on their surfaces.08:34, 25 March 2015 (UTC) (talk)Cite error: There are <ref> tags on this page without content in them (see the help page).