Talk:Bohr effect

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Point of Clarification[edit]

According to my animal physiology professor, he said multiple times in lecture that while pH and CO2 levels can cause a Bohr effect, a change in temperature does not. Anybody know? Rrten00 23:34, 31 October 2006 (UTC)

Bohr originally recorded the dependence of O2 affinity on the concentration of CO2. It was later learned that the dominant process underlying his observation was the effect CO2 had on the pH of the solution. Therefore, the dominant phenomenon of the Bohr effect is dependence of O2 affinity on pH. The dependence of O2 affinity on temperature is not the Bohr effect, nor are dependencies of O2 affinity on phosphate concentration, chloride concentration, hemoglobin concentration or any number of other factors. For an excellent review of the Bohr effect, see:

The Nature and Significance of the Bohr Effect in Mammalian Hemoglobins Austen Riggs The Journal of General Physiology(43)737-52.

Since that review, work has been completed that identified amino acid side chains in at least human and lamprey hemoglobins that contribute to the Bohr effect in these proteins. There are many studies including this one

Biochemistry, 36 (22), 6663-73.

Error on diagram??[edit]

Please can someone clarify the dissociation curve diagram. The Bohr effect text in blue on the diagram surely should read "DECREASED pH". Please clarify. Thanks. Benmoor (talk) 20:52, 3 August 2008 (UTC)

Yes, you are right. The chemical equation shows that increasing CO2 forms more H+ and will decrease the pH. However Wikipedia does not allow one to edit an image as easily as editing text; it is necessary to edit and re-upload the original image file. I will leave a note at the talk pages of the editors listed in the Original update log (Aaronsharpe and Ratznium). Dirac66 (talk) 21:21, 3 August 2008 (UTC)

Done; I changed it on Commons. DS (talk) 01:20, 4 August 2008 (UTC)

Acidic reaction with hemoglobin[edit]

The reactions shown are only CO2 and H2O. How about with hemoglobin, so that's: Hb + H+ → Hb.H, making hemoglobin less attractive for being bound by other oxygen 129.180.166.53 (talk) 10:24, 10 June 2012 (UTC)

Effect discoverer?[edit]

The corresponding article in Russian Wikipedia states that the effect was first discovered in 1898 by the Russian physiologist Bronislav Verigo (ru) and, independently, in 1904 by Christian Bohr. The Russian article cites the 2000 Large Medical Distionary (Russian: Большой медицинский словарь) as a source, and this information appears there, indeed: link (Russian). DmitTrix (talk) 07:56, 10 July 2013 (UTC)