Talk:Burkitt's lymphoma

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In[edit]

In Harrison's Principles of Internal Medicine, 16th edition, chapter 97, it says that Burkitt's lymphoma "is the most rapidly progressive human tumor". However, elsewhere I read that about ovarian Endodermal sinus tumor, previously known as Yolk sac tumor. Does anyone know anything about it? Ehudzel 22:55, 9 February 2007 (UTC)

I had Burkitt's lymphoma as a 6-year old back in the mid-1980's and at that time there was very little pediatric protocol... I was like a guinea pig for treatment, but one thing the doctors knew for sure was that it had to be attacked quickly and throughly b/c this lymphoma was known industry wide to be capable of doubling its size in less than 24 hours. Hence, I underwent chemotherapy, radiation, and over 12 hours of surgery. —Preceding unsigned comment added by 216.201.151.10 (talk) 21:02, 18 February 2008 (UTC)

The article states that "Normal B cells possess rearranged immunoglobulin heavy (IgH) and light chain genes, unlike most T-cells and other cells of the body in which the genes are germline". This is true in so far as only B cells have distinct Immunoglobin Heavy and Light Chains. However, T cells DO undergo gene rearrangement to produce unique T-cell Receptors using the same mechanisms as found in B cells. Like B cells they start their development with a germline DNA canvas and both sets of cells will mature into lymphocytes with unique receptors structurally suited to their role in antigen-binding. Allasse Lossehelin 15.03.08

Regarding the comment on IgH gene in T-cells. Actually, T-cells or probably all cells in the body possess IgH and light chain gene but B-cells rearrange them. In rare situation of T-cell lymphoma, rearrangement of IgH or light chain gene may be detected. This phenomenon is sometime referred as lineage infidelity. Wilflo. —Preceding unsigned comment added by 210.0.229.224 (talk) 09:29, 9 July 2009 (UTC)

Photographs: one reversed[edit]

If these 2 photos are of the same patient, then one of them has been reversed from the transparency (take a look at which side the tumour is located). Plutonium27 (talk) 04:09, 8 July 2008 (UTC)

Probably from different patients as one appear involving the lower jaw and another the upper jaw. Wilflo

Unless this 7 year old boy's parents have specifically given consent to have his face - which is generally considered enough to confirm identity and is protected information - this picture is a violation of patient confidentiality. It's an excellent photograph - if the appropriate people cannot be contacted, the eyes should be blacked out by horizontal bars, as is standard in medical literature to protect patient privacy. Glacialfury (talk) 14:04, 23 September 2009 (UTC)

Adults[edit]

doi:10.1111/j.1365-2141.2011.08877.x review on BL in adults. JFW | T@lk 22:37, 19 September 2011 (UTC)

Lancet Seminar doi:10.1016/S0140-6736(11)61177-X JFW | T@lk 20:27, 29 April 2012 (UTC)

AIDS sufferers[edit]

The statement 'Burkitt's lymphoma is usually associated with over 90% of AIDS cases' seems a bit far fetched. Firstly it has no citation and secondly 90% of AIDS sufferers having Burkitt's Lymphoma seems very high. Doctor Whiskey (talk) 21:11, 25 January 2012 (UTC)

Chemotherapy Protocol Incorrect[edit]

The reference for the chemo protocols cites a paper dealing with Diffuse Large B-Cell Lymphoma, not Burkitt's Lymphoma. Although the DA-EPOCH-R looks very promising for Burkitt's, the protocol is still undergoing clinical trials and is not yet appproved for wide-scale use. The current protocols can be found on emedicine. However, I am still learning this material and don't want to edit up anything that could turn out to be incorrect. — Preceding unsigned comment added by 89.100.9.94 (talk) 21:20, 9 December 2012 (UTC)