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- 1 note
- 2 New antidepressant drug increases 'brain's own cannabis'
- 3 Deficiency?
- 4 THC synthesis pathway: reference needed
- 5 Percents and times
- 6 This article should be divided
- 7 Cannabinoids and parkinson
- 8 Merge
- 9 Cyclidization
- 10 CBD is psychoactive
- 11 The intro paragraph should be re-written -- too influenced by the weed
- 12 THC-C4
- 13 Other CB sources?
- 14 CBD Contradiction
- 15 Is there a scientific term for butane extracted cannabinoids?
- 16 on the order of over 60 cannabinoid naturally occurring cannabinoid molecules / chemicals in the marijuana plant?
- 17 Cannabidiol Discrepancy
- 18 "The endocannabinoid 2-AG has been found in bovine and human maternal milk."
- 19 Cancer anti-tumor effects of cannabinoids
- 20 " natural occurence"
- 21 endocannabinoids
- 22 Added link to CRUK blog
- 23 Which cannabinoids are shared by Echinacea and Cannabis?
- 24 subsection discussing one US Patent from NIH
- 25 table of "natural cannabinoids"
in section "Cannabinoids",
- the sentence on reversible binding and stereoselectivity should be explained in more lay terms
- are all of these insoluble in water and soluble in fats, alcohols, etc?
in section "Herbal cannabinoids",
- "21 carbon compounds": do you simply mean that they contain 21 carbon atoms?
Also, the chemical discussion here is written such that it might be general, abo ut all cannabinoids, not just the herbal ones. is this correct or not?
- - Centrx 22:14, 25 May 2004 (UTC)
New antidepressant drug increases 'brain's own cannabis'
Someone with more experience in this subject ought to add information regarding synthetic THC analogues. In particular, THC-V seems interesting because it is 500 times more potent than THC (on the order of LSD's potency). http://www.erowid.org/archive/rhodium/chemistry/thc/index.html
I've heard some talk about "endo-cannabinoid deficiency" as a possible syndrome similar to chronic fatigue (or other symptoms, depending on whom you ask) ... Is this a real working medical hypothesis, or just some wishful thinking by potheads? Google doesn't turn up much on the subject, however that in itself doesn't mean it's not true... Rainman420 06:25, 13 May 2006 (UTC)
It is a real theory put forward by (presumably not pot-head) scientists. Here is a link to the abstract for a review paper in which cannabinoid deficiency syndrome is proposed: []. That said, it is still in an infant theory stage, and needs to be tested. Just as an FYI, a good place to look for information on this kind of thing (as long as it is biomedically related) is PubMed[]. Hope this helps! --MudPhud 18:53, 14 July 2006 (UTC)
THC synthesis pathway: reference needed
The article currently states: " Due to molecular similarity and ease of synthetic conversion, it was originally believed that CBD was a natural precursor to THC. However, it is now known that CBD and THC are produced independently in the cannabis plant. "
Mahlberg and Kim (http://www.hempreport.com/issues/17/malbody17.html) state "Delta 9-tetrahydrocannabinol (THC) is derived from CBD." This is supported by the following reference: Lanyon, V., J. Turner and P. G. Mahlberg. 1981. Quantitative analysis of cannabinoids in the secretory product from capitate-stalked glands of Cannabis sativa L. (Cannabaceae). Bot. Gaz. 142:316-319.
Hillig and Mahlberg (2004 http://www.amjbot.org/cgi/content/full/91/6/966) state that "Cannabigerol (CBG) is the direct precursor of cannabichromene (CBC), cannabidiol (CBD), and 9-tetrahydrocannabinol (THC) (Taura et al., 1995 , 1996 ; Morimoto et al., 1997)." This does not explicitly state that CBD is never a precursor to THC. Perhaps the cited material does make that statement, but if that is the case, then it should be explained in the article, with appropriate citation. Chondrite 20:45, 6 August 2006 (UTC)
Percents and times
This article said that HU-210 is 100-800 times as powerful as THC. the HU-210 article says it's 100-800 percent more powerful! Which is it? I brought this article in line with the "main" one (i.e., HU-210), but couldn't find any confirmation one way or the other in independent sources. Then again, I'm not a biochemist. Anyone? --tgeller 05:10, 11 October 2006 (UTC)
i've read that it was sold on a pharaceutical research chemical website and it said it was 100x as potent i believe. yes, here is the link: http://www.marijuana.org/mydna10-12-05.htm
This article should be divided
This article is too long. It mainly deals with natural compounds of the cannabis plant and many of the compounds mentioned in the Table of natural cannabinoids does not bind to the cannabinoid receptors. In the scientific literature the term cannabinoid includes all chemicals that bind to the cannabinoid receptors (natural and synthetic cannabinoids, cannabinoid agonists and antagonists, like rimonabant). Synthetic cannabinoids are much more potent than natural ones. Synthetic cannabinoids are important research tools and many of them have been shown to have therapetic potential and are in drug development, which makes them more interesting and important than natural cannabinoids. I suggest that this article will be divited into sections:
- Natural cannabinoids (of the cannabis plant)
- Synthetic cannabinoids
--Tanevala 15:28, 19 November 2006 (UTC)
Go for it, SqueakBox 18:15, 19 November 2006 (UTC)
- Readable prose at Cannabinoid is approximately 20K, and so by article size guidelines it should not be split. There's plenty of room to expand the article before a split is needed. Chondrite 17:12, 20 November 2006 (UTC)
Cannabinoids and parkinson
I Oppose the merge on the grounds that cannabinoids are a sufficiently large category of drug to warrant their own article separate from the endocanainoid system. --Selket Talk 22:37, 16 February 2007 (UTC)
If this is the page to discuss the merging-I oppose
if someone wants to point out the lack of valid point in legislature (what would be the only reason for merging I can think of) then there are (I assume) articles dealing with this specific issue Okyea 01:48, 20 March 2007 (UTC)
I OPPOSE the cannabinoids themselves should be LINKED to the endogenous system page yes but merged, definitely not. Too large and sufficiently different in content (i assume based on knowledge of the system i have not checked the article)
Opposed- This article is about chemicals not systems. Ccroberts 04:55, 5 May 2007 (UTC)
I Oppose the merge for the reasons already stated - there's far too much non-overlapping information. St3vo 18:44, 12 October 2007 (UTC)
I oppose it also, even though they are closely linked in scope. Perhaps a for further information tag should be placed. Rhetth 05:10, 23 October 2007 (UTC)
- Great idea. I put a "Details" link in the lead of the "Endocannabinoid" section and summed up the Endocannabinoid System article as well as I could. Does that satisfy everyone re: the proposed merge?St3vo 19:57, 23 October 2007 (UTC)
What is meant by the second column in the table of natural cannabinoids. What are they meant to illustrate? Whats up with the unpaired oxygen? Is it negativly charged or what?
184.108.40.206 14:39, 2 March 2007 (UTC)
It's just the carbon-oxygen backbone (the connectivity) of the molecules to illustrate the cyclization pattern. Real chemical structures are give for the compounds itself. Cacycle 03:01, 20 March 2007 (UTC)
CBD is psychoactive
Anything that crosses the BBB is psychoactive. CBD certainly does. In the same paragraph that the article says it doesn't the article reads "Medically, it appears to relieve convulsion, inflammation, anxiety, and nausea. CBD has a greater affinity for the CB2 receptor than for the CB1 receptor. It is perceived to have more effect on the body." So how is not psychoactive? All of the other cannabinoids are too. —Preceding unsigned comment added by 220.127.116.11 (talk) 01:35, 12 September 2007 (UTC)
- Nearly everything that crosses the blood-brain barrier is NOT psychoactive. I suggest that you read the article psychoactive drug. Only anxiety effects would count as psychoactive effects, but this is nothing that you could easily notice, and definitely not the kind of psychoactivity of THC. Almost all cannabinoids are not known to be psychoactive. Cacycle 02:21, 12 September 2007 (UTC)
- CBD is most certainly a psychoactive compound. It is currently being studied as an alternative treatment for schizophrenia, having antipsychotic properties, and as antipsychotics are considered to be psychoactive, CBD certainly must be as well. Any compound which has a measurable effect on the brain by binding to neurotransmitter receptor sites is psychoactive. CBD binds with CB1 and CB2 sites as an antagonist, directly competing with endocannabinoids(created by the body) as well as delta-9 THC(edit: further reading shows this is not precisely true, it is an indirect antagonist, but the reasoning holds true). Any substance which binds to a receptor site directly interferes with the brain's ordinary functioning, however small or large the effect, by either agonistic activity, antagonistic activity, or simply blocking of that receptor's ordinary function. That is the definition of a psychoactive drug, or at least what is taught in pharmacology/related classes in university. To put it another way; although there is a temptation to define 'psychoactive' as a property of euphoric or hallucinogenic drugs, this is a definition derived from pop-culture, not science, and is incorrect for a scientific article on the subject. Finally, the actual wiki page on the CBD compound lists it as a psychoactive drug, and this small entry is in direct contradiction with the primary article.HarleArmistice (talk) 15:40, 14 December 2009 (UTC)
The intro paragraph should be re-written -- too influenced by the weed
When I read the intro paragraph, I think that cannabinoids refer to the reefer, and that isn't entirely correct. Unless there's some major opposition, I'm going to re-write it to reflect the edogenous and exogenous nature of the chemical. Rhetth 05:13, 23 October 2007 (UTC)
Is THC-C4, the analogue of THC with a four carbon chain instead of five, be agonistic, antagonistic or not active at all? —Preceding unsigned comment added by 18.104.22.168 (talk) 03:59, 21 December 2007 (UTC)
Other CB sources?
- I don't believe that's true; to my knowledge, the only natural source of phytocannabinoids is cannabis (see Di Marzo, et al. 1998). However, many cannabinoid compounds such as anandamide and THC are also active at TRPV1, the receptor for capsaicin (the chemical responsible for the "spice" of hot peppers such as the jalapeño). Does that help? St3vo (talk) 22:00, 13 February 2008 (UTC)
- TRPV1 is not considered part of the eCB system, but rather the endovanilloid system. That said, the systems overlap quite a bit in distribution and ligands (in fact, the first endogenous TRPV1 ligand was the endocannabinoid anandamide). For a good review, see Starowicz, Nigam, and Di Marzo, 2007. St3vo (talk) 16:56, 29 February 2008 (UTC)
Medically, it appears to relieve convulsion, inflammation, anxiety, and nausea. CBD has a greater affinity for the CB2 receptor than for the CB1 receptor. It is perceived to have more effect on the body."
Yet in the cannabidiol article, it says that it does not bind to either receptor.
Is there a scientific term for butane extracted cannabinoids?
- It does not matter how cannabinoids are extracted, they do not change their structure. You just get less other contaminants in your complex mixture. Cacycle (talk) 23:11, 15 May 2008 (UTC)
That's not true. Isocannabinoid molecules look completely different than cannabinoids and I believe they have a different psychoactive effect. —Preceding unsigned comment added by CosmologyProfessor (talk • contribs) 06:30, 16 May 2008 (UTC)
on the order of over 60 cannabinoid naturally occurring cannabinoid molecules / chemicals in the marijuana plant?
If you do a google search for "60 cannabinoids", over one hundred and fifty thousand article hits appear, many claiming that marijuana has 'over 60 cannabinoids' (unique chemicals to the cannabis plant in nature) and anywhere from 200 to 400 other chemical ingredients. The article here doesn't touch on anywhere near that many, or even mention the order of how many natural cannabinoids exist in the plant, the list if very small in comparison even with the synthetics counted among them. Have they all been classified? I doubt the synergistic activity of each one with the other has been studied in a way that is thorough enough to say they all lack psychoactive effect except THC. CBN, CBD & THCV have been shown to have a psychoactive effect when present in the brain with THC, for example. Though my main concern is the lack of the number given in the article in comparison to the number easily found through sources. Maybe it is so long as to require a 'list of cannabinoids' article? 22.214.171.124 (talk) 12:29, 25 October 2008 (UTC)
Under the Cannabidiol heading, there is a statement that:
Cannabidiol has no affinity for CB1 and CB2 receptors but acts as an indirect antagonist of cannabinoid agonists.
Yet shortly afterwards, a contradicting statement of:
CBD has a greater affinity for the CB2 receptor than for the CB1 receptor.
- I assume might be if we take the second writing of 'receptor' that what is instead meant is the indirect means of antagonism for CB2 is greater. Nagelfar (talk) 09:35, 25 December 2010 (UTC)
"The endocannabinoid 2-AG has been found in bovine and human maternal milk."
Perhaps a route to making a synthetic 2-AG agonist for weening human babies off of their mother's milk without the disconnect of a physical rejection. Toward the purposes of where there's perception that the primal life stage harbors the creation of psychological issues by such otherwise innocuous type of forced detachment pre-verbally and that such has a real existence in that school of therapy, and this type of empirical experimentation done for a help at proof to those theories in deep rooted psychology I possibly see as a reasoning for their delving into and undertaking. (where neuropsychology takes from neurobiology) Nagelfar (talk) 09:32, 25 December 2010 (UTC)
Cancer anti-tumor effects of cannabinoids
There have been a number of studies that have been performed with cannabinoids that have demonstrated potent anti-cancer effects. This 'Nature' review by Dr. Manuel Guzmán covers a number of them: http://americanmarijuana.org/Guzman-Cancer.pdf Shouldn't this be covered in this article? 126.96.36.199 (talk) 01:31, 12 April 2011 (UTC)
" natural occurence"
I have a combination of Latico-Bodig and Lou Gehrig's disease. My rilutek was increased from 30 mg to 50 mg because I inherited both diseases from my father (I took a gene test). I also am on my endocannabinoids which are providing new motor neurons through neuro-genesis through CB1s. I used to be on medical marijuana and never got stoned. I had these diseases since 2006 and was rediagnosed in April of 2012 finding a dangerous result when the neurologist did a electro-conductor test on my left leg. I take tai chi and kung fu and have a Chinese foot massage once a week. My endocannabinoids are healing my left foot and in the mean-time with my rilutek tremendously slowing down these diseases. I also lift weights three times a week and take yohimbe and levitra so I can have sex with my wife. I am Bisaya and my wife in Micronesian. I was born in Tampa, Florida and my wife was born in Oakland. I am a Baha'i by faith. — Preceding unsigned comment added by Hechavez (talk • contribs) 01:00, 31 May 2012 (UTC)
I've added a link to a blog authored by my organisation (Cancer Research UK) in the 'Further Reading' section, summarising the state of evidence wrt cannabis and cannabinoids. I suspect this may ruffle a few feathers but it is entirely evidence-based and, I hope, a useful addition to the page. If this violates any rules, feel free to amend, clarify or even delete :) — Preceding unsigned comment added by HenryScow (talk • contribs) 09:49, 26 July 2012 (UTC)
I've tagged this statement A significant number of cannabinoids are found in both Cannabis and Echinacea plants because it is not clear. Does it mean 'between the two, though shared by neither', or 'the two plants contain many of the same cannabinoids'?
This needs to be made clear, and more information is needed which is the reason for the tag. Which cannabinoids do they share? If none, how many cannabinoids does each plant offer to make up the "significant number"? Personally, I would love to know. Thanks. petrarchan47tc 20:15, 3 January 2013 (UTC)
- For now, I removed the "are found in both" statement and the tag. petrarchan47tc 20:27, 3 January 2013 (UTC)
subsection discussing one US Patent from NIH
I deleted the section discussing one patent. There are over 200 issued patents in the US alone covering cannabinoids. http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=0&f=S&l=50&TERM1=cannabinoid&FIELD1=ABTX&co1=AND&TERM2=&FIELD2=&d=PTXT
table of "natural cannabinoids"
the article discusses phyocannabinoids and another one on endocannabinoids, then at the bottom, a "Table of natural cannabinoids". The table is not sourced (is it copied from somewhere?) and it is not clear what is phyto- and what is endo-. I think perhaps this table should go, as wikipedia is not a textbook.... what do you think? Jytdog (talk) 01:59, 21 April 2013 (UTC)