|WikiProject Chemistry||(Rated Start-class, Mid-importance)|
I removed the hyperlink in "carbamic acid" because it redirected to the same page (carbamate)Hnc 06:50, 9 December 2006 (UTC)
It is not accurate to say that K<<1 for the carboxylation of an amine because the C-N bond is labile. K<<1 is a statement of thermodynamics which suggests that the amine and the fully oxidized CO2 are more stable than the carbamate product. Suggesting that the C-N bond is labile is a statement of its kinetics, meaning that it takes little energy to get to this reaction's transition state. I imagine the author meant to say that the C-N bond is less stable.
terminal carbamic acids
- Some carbamic acids have been isolated and even had their crystal structures determined: Chem. Commun. (2000), 1099-1100.
I take issue with the sentence that states carbamate esters are reversible inhibitors of acetylcholinesterase. They actually carbamoylate the active site serine in an analogous manner to phosphorus esters, which phosphorylate the same serine residue. However, although the carbamoylated group is hydrolysed at a faster rate than phosphorylated serine, they are still not reversible inhibitors in the strict sense.22.214.171.124 (talk) 18:16, 12 November 2012 (UTC)Philip Jewess