Talk:Carboplatin
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[edit] Arrows in carboplatin figure
What's the deal with the arrows connecting the patinum atom to the amino groups? Shouldn't those arrows be simple lines representing single bonds? --David Iberri (talk) 09:29, 22 April 2008 (UTC)
They represent dative bonds (i.e. the nitrogen donates its lone pair to the platinum). In reality either would be acceptable. — Preceding unsigned comment added by 130.88.233.248 (talk) 16:28, 27 February 2012 (UTC)
[edit] Formula vs molecule weight discrepancy?
the main page says "Formula C6H14N2O4Pt" and "Mol. mass 371.249 g/mol", however in the picture shown I see only 12 hydrogen atom white balls, and if you add up the weight of all atoms, 14 H's gives you 2 higher than the 371 weight.
The main page's link to "PubChem 498142" shows a formula having only H12 with a weight of 371.24848, and that molecule has a charge of negative 2, because it somehow takes an H away from each of the nitrogen atoms, but gives a 3rd bond to the oxygens instead of the normal 2. Same story for the drawing at the ATC code link.
At PubChem, if you click on the link for similar compounds, you do find another molecule of the same formula wiht H14, having a weight of 373.26436, and somehow it goes from negative-2 to positive-2 while adding 2 H's. Silversplash (talk) 05:37, 2 August 2009 (UTC)
[edit] Side Effects section - Cisplatin vs. Carboplatin
Recently, an IP user made an edit, without explanation, that deleted the following text from the first paragraph of the Side Effects section:
- Carboplatin has also proven effective in some strains of cancer that may not be susceptible to cisplatin, including germ-line cell, small and non-small cell lung, ovary, and bladder cancers, as well as acute leukemia.
This deletion may be entirely appropriate.
- The Side Effects section isn't the correct place to note a difference in efficacy of carboplatin vs. cistplatin
- The assertion is unreferenced
- I'm not aware of such a difference
- The terminology used ("some strains") is inaccurate.
I "undid" the deletion for procedural reasons, but I think it is correct to actually delete it. Does anyone have any comments on the matter?
Thank you, JoeSperrazza (talk) 22:19, 18 December 2010 (UTC)
- The same editor made the change again, but this time included an edit summary. I agree with the change. JoeSperrazza (talk) 16:01, 19 December 2010 (UTC)
