Talk:Cell cycle

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This article has comments here.

Article's quality[edit]

Does it describe Eukaryotic cells or all cells ? Do all cells folow this cycle or are there some exceptions ? -- Taw

I think this is specific only to eucaryotes, but among these, the mechanism is fairly conserved from yeast to man. AttishOculus 22:19, 11 Jun 2005 (UTC)

Is there a reason to have this article separate from Cell division and Mitosis - Marshman 05:46, 30 Sep 2003 (UTC)

Yes. Mitosis is only one small part of the cell cycle. There is more than enough information about mitosis to justify its having its own entry, but it should not be combined with cell cycle. ~mdash; Brim 17:38, Nov 27, 2004 (UTC)

I think this topic would deserve some additional, more detailed information. (exeact transitions, checkpoints, cyclins, CDK's and CKI's in detail etc.) I would be glad to add some more information, regarding the importance of the subject (in cancer research, for example), but as I am only a I could use no other source of knowledge but my textbooks, so I would be happy to have an expert look through my work every once in a while.

Additionally, I fear that stacking up the article with scientific info would make the whole article frightening and overwhelming for non-professionals. What would you recommend in order to avoid that? Would having separate sections in the article after the current one as an introduction be sufficient, or would it be better to add a new article "Cell cycle in detail", or just have a number of new pages linked into the main page (eg. "Replication initiation mechanisms")? What would be the general Wikipedia practice in such cases? AttishOculus 22:19, 11 Jun 2005 (UTC)

This article lacks so much info...i mean a lot. I came here looking for help on the topic--because i just couldn't understand some of it, and it wasn't here. All of the stages require info of the cell cycle. The Mitosis part deserves its own part. The cycle's checking system needs its own part. This is one bad article. I'll try to fix it in a day or two after my test. :) Nominaladversary 01:54, 31 March 2006 (UTC)

The mitosis part has its own part at mitosis. I'd bet my boots check points will also direct you to the cycle's checking system too. Aaadddaaammm 07:10, 19 October 2006 (UTC)

Image of cell cycle regulation is wrong. Cyclin E-CDK2 complex regulates G1/S checkpoint, not G2/M; and vice versa for Cyclin A-CDK2 complex. A correct image is accessible here: http://en.wikipedia.org/wiki/File:Regulation_of_cell_cycle.png --Iflex (talk) 06:49, 10 September 2010 (UTC)

No description of basic process of cell division[edit]

There has to be a section dvoted to description of all phases during mitosis (and variations during a meiosis). The article seems to dwell heavily upon recent advances in molecular biology. These advances have to be placed in perspective with the general biology of the cell cycle Nattu 20:21, 16 June 2006 (UTC)

This article is a recent retooling of a rather poor, stubby original. Currently mitosis and meiosis have their own articles, which are in a much better state than this one was; the phases of mitosis also have their own articles. There's an emphasis on molecular biology in the current article because I wrote it :) Feel free to add more general information, as I think in time this article should evolve to be a proper header for Category:Cell cycle.
Yes, the mol bio part is good and we can shape it further. For now, emphasis must be on cell cycle basics and I will contribute my bit to it. Nattu 19:19, 23 June 2006 (UTC)

Cell Cycle Regulation Diagram Removed[edit]

The current illustration of the cell cycle should be removed or replaced in my opinion. It would almost have been ok if all the phases seemed to have equal duration. But in this illustration S phase is actually smaller than the G2 phase! - HungryHippo 19. july 2006

You're right, it's not really very good, but I do think it's better than nothing (especially given the explanation of its deficiencies in the caption). I've posted a {{Diagram requested}} in the hopes of attracting a good diagram creator, which I am not. Opabinia regalis 02:07, 20 July 2006 (UTC)


The second diagram on this page is horrificly inaccurate. How it can center around CDK2 when it has been shown that this is redundant to CDK1?

Berthet, C., E. Aleem, V. Coppola, L. Tessarollo, and P. Kaldis. 2003. Cdk2 knockout mice are viable. Curr. Biol. 13:1775–1785.

The Journal of Cell Biology, Vol. 178, No. 2, July 16, 2007 257–268

Please consider revision of this image! —Preceding unsigned comment added by 129.31.120.113 (talk) 11:34, 8 July 2009 (UTC)

I removed the diagram in question because of several patent falsehoods in addition to those already mentioned: i.e., Cyclin-B complexes with CDK1 to resolve the G2-to-M checkpoint. In the diagram, CyclinE/CDK2 is depicted in that role, which is not the case. The Cyclin-E/CDK2 complex actually resolves the G1-to-S checkpoint, which leads to another inaccuracy in the diagram: Cyclin-A/CDK2 do not resolve G1-to-S, as shown, but rather the S-to-G2 checkpoint. Because of this, I removed the diagram from the page, as it is too misleading to be useful. Link to removed file: http://en.wikipedia.org/wiki/File:Regulation_of_the_cell_cycle.svg —Preceding unsigned comment added 11:24, 18 May 2011 (UTC)

About diploid, haploid and monoploid[edit]

"In this quantity of DNA within the cell has increased to 4c, but the cell is still considered diploid." Finally i got the information.

embryology[edit]

Does anyone happen to know any embryologists? I think Embryology really needs a lot of expert attention. would sympathtic editors consider a positive vote here? [1]Slrubenstein | Talk 19:05, 28 August 2006 (UTC)


Mitosis vs. M phase[edit]

As far as I know M phase=Mitosis+Cytokinesis, but there is no article on M phase, only on Mitosis, and in the picture:

Schematic of the cell cycle. I=Interphase, M=Mitosis. The duration of mitosis in relation to the other phases has
been exaggerated in this diagram

, I think, M phase is denoted by letter "M" and not Mitosis, as there are four phases: G1, S, G2 and M (+G0). Should the text below the picture be changed?

Andrius 14:49, 29 October 2006 (UTC)

About the diagram[edit]

I can make a fairly good diagram, but I am not an exepert on cellulear procesess, so e-mail me with even a napkin drawing of the correct process and I'll "pimp it out". thanks

Yupi666 20:15, 14 June 2007 (UTC)

Copyedit and minor expansion[edit]

I have done some minor expansion and copy-editing and fixed some formatting issues. I will be adding some references in the coming one or two days. Please comment here if there are any errors or omissions. Also, I think it would be better if we do away with the Observation and Research Groups sections. Also, Regulation of cell cycle can be greatly expanded. Or can be made into a totally separate article. Any comments? - TwoOars 10:46, 1 August 2007 (UTC)

References[edit]

Added a few references. Am removing the "refs needed" tag. I do not know how to add inline refs though, for the rest of the stuff - I mean the basic stuff about the phases, which is found in any basic textbook. Am assuming inline refs are not needed in such cases. - TwoOars 19:23, 1 August 2007 (UTC)

I've added a "citation needed" tag to the claim, in the section on S phase, that transcription and translation are low during S phase. Does anybody know if this is perhaps organism specific? In any case, I found no reference for it, and it doesn't actually make a lot of sense considering the length of the S phase in (for example) mammalian cells and the fact that cells grow continuously through S phase. Also, this phenomenon isn't mentioned in the article on the S phase. 155.198.165.46 (talk) 14:23, 29 July 2011 (UTC)

The template[edit]

As an aside, how about adding links to the checkpoints from {{Cell cycle}}? Please comment at Template talk:Cell cycle. Thanks. - TwoOars 18:20, 3 August 2007 (UTC)

Never mind. Has been taken care of by Arcadian. - TwoOars 17:07, 4 August 2007 (UTC)
Nobody should be an aside in Wikipedia - feel as free to edit as anybody! Mikael Häggström 16:30, 5 August 2007 (UTC)

Another problem with the diagram[edit]

The Yellow "M" should not refer to Metaphase but to mitosis again. The counterpart of interphase is not the metaphase but the mitosis which include prophase, metaphase, anaphase and telophase.—Preceding unsigned comment added by Vardos (talkcontribs)

You are right. I changed it. I don't know how we missed it all this while, that too after a monthly collaboration. :P - TwoOars (Rev) 16:03, 7 October 2007 (UTC)

Why only eukaryotes?[edit]

The term Cell Cycle can apply to both prokaryotes and eukarotes, but the article focuses entirely on eukaryotes. In my opinion the article can be strengthened with an additional prokaryote section....or at the minimum, include some sort of reference to prokaryotes. --Naturespace (talk) 04:56, 5 December 2008 (UTC)

Quality[edit]

i would just like to note that my grade 9 science textbook has better descriptions on what actually happens in cell division and if i remember correctly there are alot more phases than the 4 mentioned.... Walkerm930 (talk) 19:40, 27 March 2009 (UTC)

I think the confusion here is that you may have been looking for the mitosis or cell division article(s) and not cell cycle. The treatment of the cell cycle in high school biology books, if it is mentioned at all, is very brief. Mitosis in contrast is treated in some depth. The mitosis stage of the cell cycle involves the physical separation of the duplicated chromosomes during cell division and is divided into prophase/prometaphase/metaphase/anaphase/telophase substages (see the diagram below the Mitosis#Preprophase section). The cell cycle, in addition to the mitosis step, involves growth of the cell and molecular replication of DNA. Cheers. Boghog2 (talk) 07:06, 28 March 2009 (UTC)
I have just added the following to the top of this article:
{{About|cellular growth, DNA replication and division|separation of chromosomes|mitosis}}
I hope this reduces the confusion. Boghog2 (talk) 20:35, 7 April 2009 (UTC)
Or even more to the point:
{{About||the separation of chromosomes that occurs as part of the cell cycle|mitosis}} Boghog2 (talk) 05:10, 8 April 2009 (UTC)

cell cycle[edit]

is a function of life and how that it wordks —Preceding unsigned comment added by 170.211.230.126 (talk) 14:20, 1 October 2009 (UTC)

quinescent phase"[edit]

I've always hated the term "resting phase." The cell is performing all of it's functions except those related to dividing, should we really refer to it as the "resting phase?" —Preceding unsigned comment added by 64.221.247.194 (talk) 12:15, 21 October 2010 (UTC) Umm Like I Didnt Understand At First But Now I Totaly Get It (:! — Preceding unsigned comment added by 66.87.0.231 (talk) 00:50, 30 August 2011 (UTC)

Diagram?[edit]

I altered one of the cell cycle diagrams to better reflect the duration of each phase of the cycle (reference) but I don’t know much about editing (or if the duration of mitosis was exaggerated for a good reason for that matter). Anyway… here it is. --Histidine (talk) 11:16, 22 January 2011 (UTC)

Your modifications to the diagram look reasonable and I would support replacing the original with this modified version. There is one minor problem however. The original is in the preferred svg format while the modified version is png. Would it be possible to produce a modified version in svg format? Boghog (talk) 13:17, 22 January 2011 (UTC)
I just tried to upload an svg version and, long story short, it did not go well the first two times (I am sorry about making a mess). It is still rendering differently then it should be, but this is the best I could do. Maybe I'll learn how to make a better one later. --Histidine (talk) 09:10, 23 January 2011 (UTC)
Thanks. Your svg version looks OK to me. The font is not as quite as clean, on the other hand I like the larger font size which makes the thumb nail depiction more legible. I think it is good enough replace the current version in the article. Cheers. Boghog (talk) 11:21, 23 January 2011 (UTC)
Yes, the font is one of the things that came out differently once I uploaded it. I read it is a bug with using Inkscape, so I might try to sort that out at some point. --Histidine (talk) 20:27, 23 January 2011 (UTC)
I think I figured out all my bugs with uploading. If no one opposes I will replace the one in the article. --Histidine (talk) 02:06, 25 January 2011 (UTC)
Thanks for fixing the remaining bugs. The graphic looks perfect. Boghog (talk) 06:04, 25 January 2011 (UTC)
Schematic of the cell cycle. Outer ring: I = Interphase, M = Mitosis; inner ring: M = Mitosis, G1 = Gap 1, G2 = Gap 2, S = Synthesis; not in ring: G0 = Gap 0/Resting.
Buggy
No more bugs?


Overall quality[edit]

The overall quality of the article is still lacking significant detail and in depth information. Different phases seem to be short and may need more information, for example S phase does not really elaborate much on its purpose. — Preceding unsigned comment added by Nvarade (talkcontribs) 02:32, 4 February 2014 (UTC)