Talk:Centella asiatica

From Wikipedia, the free encyclopedia
Jump to: navigation, search
          This article is of interest to the following WikiProjects:
WikiProject Vietnam  
WikiProject icon This article is part of WikiProject Vietnam, an attempt to create a comprehensive, neutral, and accurate representation of Vietnam on Wikipedia. If you would like to participate, please visit the project page.
 ???  This article has not yet received a rating on the project's quality scale.
 ???  This article has not yet received a rating on the project's importance scale.
 
WikiProject Plants (Rated Start-class, Mid-importance)
WikiProject icon This article is within the scope of WikiProject Plants, a collaborative effort to improve the coverage of plants and botany on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.
Start-Class article Start  This article has been rated as Start-Class on the project's quality scale.
 Mid  This article has been rated as Mid-importance on the project's importance scale.
 
WikiProject Alternative medicine (Rated Start-class)
WikiProject icon This article is within the scope of WikiProject Alternative medicine, a collaborative effort to improve the coverage of Alternative medicine related articles on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.
Start-Class article Start  This article has been rated as Start-Class on the quality scale.
 
WikiProject India (Rated Start-class, Low-importance)
WikiProject icon This article is within the scope of WikiProject India, which aims to improve Wikipedia's coverage of India-related topics. If you would like to participate, please visit the project page.
Start-Class article Start  This article has been rated as Start-Class on the project's quality scale.
 Low  This article has been rated as Low-importance on the project's importance scale.
 
Note icon
This article was last assessed in March 2012.

Citations Needed[edit]

Citation nr 24 is "Centella asiatica (L.) Leaf Extract Treatment During the Growth Spurt Period Enhances Hippocampal CA3 Neuronal Dendritic Arborization in Rats K. G. Mohandas Rao1, S. Muddanna Rao2 and S. Gurumadhva Rao3; Advance Access Publication 14 June 2006 eCAM 2006" available here http://downloads.hindawi.com/journals/ecam/2006/627102.pdf — Preceding unsigned comment added by 86.111.103.70 (talk) 22:47, 20 December 2012 (UTC)

Should the claim at the end about a guy living to 124 have a source, and other things to, such as "In addition, preliminary evidence suggests that it may have nootropic effects."

I've added citation needed markers to the mentioned unsourced statements. 24.220.79.116 23:43, 28 January 2007 (UTC)

I've created a new section for the unverifiable bits, "Folklore". Kitarra 01:01, 29 January 2007 (UTC)

I have added citations and removed the citation needed markers. I also corrected the Richard Lucas information- he may have popularized the herb, but he got the species wrong, assumed a nonexistent subspecies and a nonexistant Vitamin X. The linked article by master herbalist Michael Moore explains more. Karen S Vaughan 13:39, 24 May 2007 (UTC)

Problem with the Widgerow citation[edit]

I tried, but this is the first time I've cited a journal and it looks as if I've bolloxed it up. Can someone tell me where I've gone wrong? 24.220.79.116 23:37, 28 January 2007 (UTC)

Aha, nevermind, it looks as if I've fixed it. 24.220.79.116 23:43, 28 January 2007 (UTC)

I've changed the link from a full-text payment-required pdf to a free abstract. Kitarra 00:59, 29 January 2007 (UTC)

Different types of Gotu Kola or entirely different species[edit]

I've noticed at least three different looking plants all claiming to be Kotu Kola, including the one pictured here:

http://mindanao.com/photoblog/?p=2516

As well as plants that look more like the one in this article's photo.

Is it possible these are all different types of Gotu Kola or is one type not the real McCoy?202.88.81.69 (talk) 06:39, 2 February 2008 (UTC)

Arthiritis[edit]

Gotu Kola is a best natural medicine against Arthiritis and other Auto Immune Diseases, but somehow it is not mentioned in the article.:Yucatann: (talk) 04:25, 27 November 2009 (UTC)

"there is no such subspecies and no Vitamin X"[edit]

I consider the definitive statement of non-existence to be unprovable. The inability of one herbalist to locate a sub-species, or isolate an active ingredient in an extract does not conclusively prove its non-existence, regardless of the herbalist's level of repute or fame. This statement should be removed, or altered to read along the lines that "investigations subsequent to Lucas' claims have been unsuccessful in locating said subspecies or Vitamin". —Preceding unsigned comment added by 1.144.119.249 (talk) 02:02, 13 February 2011 (UTC)

Hepatotoxicity[edit]

Some studies suggest that consumation of Centella asiatica (Gotu kola) can result in Hepatotoxicity (ie. toxic for the liver), and of course pregnant women should avoid it in any case.-- 77.119.156.92 (talk) 10:58, 14 September 2011 (UTC)

some studies that might be included[edit]

"Anticancer activity: A large number of experimental reports proved that different solvent extracts of C. asiatica has anti-cancerous activity. In vitro study on HeLa, HepG2, SW480 and MCF-7 cell lines showed that methanolic extract had induced apoptosis in human breast cancerous MCF-7 cells (Babykutty et al., 2009). Water extracts induced apoptosis in colonic crypts and exerted chemopreventive effect on colon tumorigenesis in male F344 rats (Bunpo et al., 2004). Asiatic acidinduced apoptosis in human melanoma SK-MEL-2 cells (responsible for skin cancer) and SW480 human colon cancer cells (Park et al., 2005; Tang et al., 2009). Asiaticosideenhanced anti-tumor activity of vincristine in cancer cells (Huang et al., 2004). Constituents in the methanol extract inhibited the proliferation of human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells (Yoshida et al., 2005)."

http://bio.sophiapublisher.com/html-607-43-mpr


Babykutty S., Padikkala J., Sathiadevan P.P., Vijayakurup V., Azis T.K.A., Srinivas P., and Gopala S., 2009, Apoptosis induction of Centella asiatica on human breast cancer cells, Afr. J. Trad. CAM, 6: 9–16

Bunpo P., Kataoka K., Arimochi H., Nakayama H., Kuwahara T., Bando Y., Izumi K., Vinitketkumnuen U., and Ohnishi Y., 2004, Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats, Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 42: 1987–1997 http://dx.doi.org/10.1016/j.fct.2004.06.022

Park B.C., Bosire K.O., Lee E.S., Lee Y.S., and Kim J.A., 2005, Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells, Cancer Letters, 218: 81-90 http://dx.doi.org/10.1016/j.canlet.2004.06.039

Tang B., Zhu B., Liang Y., Bi L., Hu Z., Chen B., Zhang K., and Zhu J., 2011b, Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts, Archives of Dermatological Research 303: 563-572 http://dx.doi.org/10.1007/s00403-010-1114-8

Huang Y.H., Zhang S.H., Zhen R.X., Xu X.D., and Zhen Y.S., 2004, Asiaticoside inducing apoptosis of tumor cells and enhancing anti-tumor activity of vincristine, Chinese Journal of Cancer, 23: 1599–1604

Yoshida M., Fuchigami M., Nagao T., Okabe H., Matsunaga K., Takata J., Karube Y., Tsuchihashi R., Kinjo J., and Mihashi K., 2005, Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica, Biological & Pharmaceutical Bulletin, 28: 173–175 http://dx.doi.org/10.1248/bpb.28.173

There are a lot of studies on other diseases listed in the original link as well. Could we include some of these in the article?

Judderwocky (talk) 01:17, 4 October 2013 (UTC)

Only if they meet the criteria of WP:MEDRS. I don't think any of these do. Alexbrn talk|contribs|COI 04:35, 4 October 2013 (UTC)

Nevermind I found the wikipedia page covering some of the journals. Food and Chemical Toxicology, for instance isn't acceptable, and looks like some of the others aren't either.

U of M seems supportive as well: http://umm.edu/health/medical/altmed/herb/gotu-kola Kortoso (talk) 21:25, 24 April 2014 (UTC)

Habitat section should specify locations where it is found[edit]

Description indicates it only grows in the tropics. That information should be specified in the Habitat section. On NIH website I found this information: "It is found in most tropical and subtropical countries growing in swampy areas, including parts of India, Pakistan, Sri Lanka, Madagascar, and South Africa and South pacific and Eastern Europe." Is that accurate? I don't usually consider Eastern Europe to be in the tropics. — Preceding unsigned comment added by Swillmarth (talkcontribs) 16:32, 21 June 2014 (UTC)