|WikiProject Molecular and Cellular Biology||(Rated B-class, Mid-importance)|
activating agent,active form, optimum pH of chymotrypsin
i may be wrong and misunderstand the author because i am not a native english speaker myself, however i believe he/she confused P and S. where the P site makes up the positions in the peptide to be hydrolysed and the S site the position in the active side of the protease interacting with the peptide to be cleave.
this can be looked up
ON THE SIZE OF THE ACTIVE SITE IN PROTEASES. I. PAPAIN BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 27, No. 2, 1967 —Preceding unsigned comment added by Lohselose (talk • contribs) 17:35, 11 June 2010 (UTC)
The illustrated mechanism is wrong. The asp 102 does not deprotonate his 57. The hydrogen at that position in histidine isn't acidic to begin with. Asp 102 merely hydrogen bonds with his 57. —Preceding unsigned comment added by 220.127.116.11 (talk) 02:05, 28 November 2010 (UTC)