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Introduction was modified to provide greater specificity and clarity on the differentiation of Ephs from ephrins. The classification of ephrin and eph subtypes was considerably expanded to distinguish between the EphA/ephrin-A and EphB/ephrin-B subtypes, which were previously poorly elaborated upon. Additionally, the reverse signaling by ephrin ligands was included as it is increasingly being recognized that ephrin ligand signaling is distinct and sometimes opposite of that mediated by Eph receptor signaling. Specific examples of ephrin reverse signaling were provided and linked to allow readers access to a more in-depth description of reverse signaling by each ephrin ligand.

The overall goal of the edits was to make the information in this page more closely reflect the information in the Eph receptor page so that the two will provide the reader with greater insight into the function and mechanisms of Eph/ephrin signaling.

Armadaskier324 (talk) 22:24, 13 December 2011 (UTC)


From this article: "Ephrins compose the largest known subfamily of receptor protein-tyrosine kinases". No information that I can find verifies this. Plenty of sources describe the subfamily as an RTK ligand. I have put a dubious tag on the statement until a citation can be provided. (talk) 16:54, 13 February 2013 (UTC)

I fixed the typo in the lead. It now reads "Ephrin receptors in turn compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs)". This is a rather strange sentence to include as the second sentence of the lead since this subject of this article is about the ligand, not its receptors. I slightly reworded it so hopefully the distinction is now clearer. Boghog (talk) 21:31, 25 February 2013 (UTC)