Talk:Free-radical theory of aging
|WikiProject Molecular and Cellular Biology||(Rated Start-class, High-importance)|
|WikiProject Medicine||(Rated Start-class, Mid-importance)|
I think less is more.
"Harman's has the most consistent experimental support."
I think this theory is a pure nonsence. In my knowleadge all aging processes involve water...so water is per se the only cause of aging...Should I continue??? Or you have got it? —Preceding unsigned comment added by 18.104.22.168 (talk) 16:17, 14 July 2008 (UTC)
Moreover a free radical is the chunk of molecule lacking electron, but there are plenty of them in the water and only electrons absorbs any kind of energy, so and thermoenergy and light, and in the thermodynamical equilibrium we always have free electrons everywhere to neutralise these radicals so THEY CANNOT ACCUMULATE (but the damage done can, so the real causes are somewhere else, but not in the existance of free radicals)!!! Thus and cannot be the cause of ageing, it's a consequence of something we do not know. Of cause they affect overall metabolism, but not more than lack or abundance of Ca ions or vitamins or hormones or any other molecules. Some even are very positive fighting with unwanted contaminating molecules or organisms (an they are the real cause of our ageing). —Preceding unsigned comment added by 22.214.171.124 (talk) 16:30, 14 July 2008 (UTC)
- Do you really think it is better this way? I agree we should keep text to a minimum, but I think that was way too much! Consider reverting to the previous version and then split the article in some new articles, making referece to thses new pages in each section. A bit like this: English history. --Jotomicron | talk 11:20, 23 Jun 2005 (UTC)
The previous version was http://www.lef.org/magazine/mag98/jan-interview98.html verbatim. I'll go through it again... Zwa 22:27, 23 Jun 2005 (UTC)
Opinions on this new layout? I think I should find a few more references on the free radical/aging link. The problem is that theres a lot. And info on antioxidant therapy. Off the top of my head, I feel that large doses of antioxidants wouldnt help a lot, and may be detrimental, but I'll look into it... Zwa 23:36, 23 Jun 2005 (UTC)
Radon and Free Radicals
4 pCi/l of airborne radon, the EPA action Guideline, results in the build-up of approximately 200 pCi of Radon Decay Products in the lungs. This in turn results in approximately 200,000,000 ion pair per second of which the vast majority are free radicals. There will be an additional quantity of radon in the blood stream also contributing to the number of free radicals.
Assuming that the 200,000,000 ion pair per second is correct, does any one have any idea of how this compares to naturally forming free radicals in the body. If interested I can supply calculations demonstrating how I arrived at these numbers.
Paul V. Jennemann firstname.lastname@example.org
This article sounds more like a scientific paper than an encyclopedia article. It's difficult for someone without a medical background to completely comprehend what this article saying. I recommend that someone rewrite this article in a way so that it's able to be easily understood while retaining all that technical information. Solarusdude 21:04, 27 September 2005 (UTC)
The references don't quite seem to match up. I think a and b in the Notes should be merged, but it probably needs someone to have a look at the article / abstract to get the correct reference notation.Gringer 13:05, 12 October 2005 (UTC)
- Argh, sorry. I just mis-interpreted the numbers. They all appear to link to the correct references. Gringer 13:08, 12 October 2005 (UTC)
i work more on the german pages, so i wont make changes here. but the citation thats needed at "Evidence: A large body of comparative biochemical evidence suggests..." might be found within Pamela Larsons Paper on "Aging and resistance to oxidative damage in Caenorhabditis elegans" Proc. Natl. Acad. Sci. Vol 90 1993. See notes 8 & 9. 126.96.36.199 (talk) 18:06, 16 April 2009 (UTC)
Criticism/counter evidence section
There have been many long-term experiments (on mice) that counter this theory (and thus the established industry). Please someone more knowledgeable add such section. --188.8.131.52 (talk) 19:20, 30 October 2010 (UTC)
I agree. I came looking for Pro & Con information. I think there should be a formal section summarizing the Criticism/Counter Evidence. Unfortunately I can add nothing. Thanks. HalFonts (talk) 03:13, 8 October 2012 (UTC)
In one laboratory, Phenybutylnitrone (PBN) was shown to produce about a 10% extension of maximum lifespan in experimental animals. However, this finding has not been reproduced by other laboratories.
If labs have tried to reproduce this study and it failed there should be a paper or something to cite. If no one has tried to repeat the study then I think this statement is misleading as is. — Preceding unsigned comment added by 184.108.40.206 (talk) 10:57, 8 January 2012 (UTC)