Talk:G-quadruplex

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sequence[edit]

d(GGTTAG) - is there a reason for this form of noting the sequence? a) as a sidenote d(sequence) probably means that it is the deoxy form of the sequence - will this be understood by the casual reader? b) why GGTTAG and not e.g. TTAGGG - it will be the Gs that form the quadruplex, so if the sequence repeats anyways, why split up the Gs? Iridos 01:40, 11 May 2007 (UTC)

a) It's the standard nomenclature, and I don't see how it could be massively improved b) There is - the enzyme telomerase, which elongates telomeres, contains an inbuilt RNA template, that adds the repeat d(GGTTAG) many times. Hence there is a starting point for the sequence. Jlh29 16:15, 7 June 2007 (UTC)

Sorry for the "drive-by-commenting" back then. As to a) I know it is standard for denoting "deoxy" and would not have objected in a scientific publication. For readers of an article in Wikipedia, I would not presume the same level of proficiency, though. To improve on it, one could either remove it altogether — and include a word that teleomeric repeats are found in DNA, which would imply the d(), or possibly link the d( to ... perhaps deoxynucleotide — well, actually somewhere that explains what it means. Such a link might violate linking conventions, so I would prefer the first solution.
b) fair enough. Then it is inconsistent, though, that the introduction to Telomerase starts with: "Telomerase is an enzyme that adds DNA sequence repeats ("TTAGGG" in all vertebrates)" (the image next to it even shows a different sequence).
Iridos (talk) 17:46, 5 July 2011 (UTC)

repeat edits/reversion[edit]

Could 202.46.222.112 and 121.247.190.198 please cease reinserting papers - wikipedia is not pubmed, and does not need multiple listings of all papers published by their group! If they would like to suggest a change, can they discuss it here first.

Potential functions[edit]

Could anyone write a few lines on what these structures might actually do? At least hypothetical ideas. --David Munch (talk) 12:38, 22 September 2011 (UTC)

I've added a (very) brief starting point, which I intend to improve upon over the next few weeks/months Sarahburge (talk) 17:40, 30 November 2011 (UTC)

Monovalent cations[edit]

I removed the word "monovalent" from the introductory paragraph; quadruplexes can happily form with divalent cations; calcium and strontium cations have both been seen in quadruplexes [1]. Sarahburge (talk) 17:31, 7 November 2011 (UTC)

Possible source[edit]

Chris857 (talk) 01:19, 21 January 2013 (UTC)
    • ^ Lee, M. P.; Parkinson, G. N.; Hazel, P; Neidle, S (2007). "Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel". Journal of the American Chemical Society 129 (33): 10106–7. doi:10.1021/ja0740869. PMID 17661470.  edit