Talk:H19 (gene)

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Why is there a part titled genome instability if it is not known whether or not this gene has a relation with it. It seems unnecessary. — Preceding unsigned comment added by (talk) 09:28, 6 January 2013 (UTC)

suggested addition Hello you dear people who watch the non-translated RNA pages -- I was at the Sanger visit for the ABSW and heard of the interest in annotating these pages. Here's a reference for you that extends interest in H19 and its microRNA / IncRNA to osteoarthritis: J Mol Med (Berl). 2012 Apr 21. [Epub ahead of print] Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions. PMID: 22527881 Cheers!Celia Kozlowski (talk) 22:14, 30 April 2012 (UTC)

A short question: How can one make a statement of the amino acid level, if it's claimed, that there's no product of translation ? —Preceding unsigned comment added by (talk) 17:48, 5 December 2009 (UTC)

Seems reasonable to me. The full quote is "Although the RNA sequence was highly conserved evolutionarily, at the amino acid level, there was a complete absence of conservation", the section is on evidence why researchers think this is a ncRNA and not a protein-coding gene. So if you take the H19 gene from many different species and translate the sequence (probably in all 3 frames) and compare these sequences you see none that show any significant level of evolutionary constraint. --Paul (talk) 21:01, 5 December 2009 (UTC)