Talk:Hepatotoxicity

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Hepatotoxicity was a Natural sciences good articles nominee, but did not meet the good article criteria at the time. There may be suggestions below for improving the article. Once these issues have been addressed, the article can be renominated. Editors may also seek a reassessment of the decision if they believe there was a mistake.

Article milestones
Date	Process	Result
November 3, 2007	Good article nominee	Not listed

Medicine: Gastroenterology / Toxicology Mid‑importance

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	This article is supported by the Toxicology task force (assessed as Mid-importance).

Pharmacology High‑importance

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picture of skin with hepatotoxicity

Article[edit]

NEJM review. JFW | T@lk 03:11, 17 February 2006 (UTC)[reply]

Hepatoxin or hepatotoxin?[edit]

All my textbooks and medical dictionaries say 'hepatotoxin' instead of 'hepatoxin.' Hepatotoxin flows off the tongue a little better, and we say 'hepatotoxic' rather than 'hepatoxic.' Google seems to agree; there are about 240 pages with 'hepatoxin' while there are more than 65,000 that contain the word 'hepatotoxin.'

What does everybody else think? It sticks out like a sore thumb to me. - BaseballBaby 06:25, 29 June 2006 (UTC)[reply]

You've had no responses since June; I shall assume it is a typo and correct it to "hepatotoxin". Fuzzypeg ☻ 02:59, 8 January 2007 (UTC)[reply]

Types[edit]

"Hepatotoxicity can be considered to occur in two forms, symptomatic or idiosyncratic."- I can't figure out what this sentence is supposed to mean. Like most medical conditions, hepatotoxicity can be symptomatic or asymptomatic and the toxicity can be dose dependent or idiosyncratic...... this article starts off well but somewhere loses the track. Trying to figure out what to do about it. Wondering what others think.--Countincr ^{( T@lk )} 23:07, 24 June 2007 (UTC)[reply]

Hy's law[edit]

This article needs to mention Hy's law (Hyman Zimmerman), as cited by Goldhaber in PMID 16618822. JFW | T@lk 19:16, 23 July 2007 (UTC)[reply]

GA Review[edit]

The article does meet the Good Article criteria, and will not be listed at the present time. There are numerous issues with several of the criteria, although on the plus side, I don't see any serious issues with neutrality or stability. All of the images used are also free, and have appropriate copyright tags. The drug metabolism image is also particularly nice,...

The article needs a very good, thorough copyedit. There are numerous elementary level grammatical errors in the article; singular/plural issues, lack of definite articles, run-on sentences, etc. I am uncertain as to how to comprehend sentences like, "Apart from acetamenophen toxicity liver function will return to normality in offending drug is stopped early."

There are numerous manual of style issues with the article as well. The header "Adverse drug Reactions" has a really obvious issue with it. Some of the other subsection headers under 'Patterns of injury' also violate the manual of style as well (remove the link from the header and put the link as a 'see also' or 'main article' link. It might also help to bump these up to 2nd or 3rd level headers, for additional emphasis.

Reference citations are insufficient. There's a lot of key information that is unsourced. One obvious case here is, "the most common reason for a drug to be withdrawn from the market." -- This definitely needs to be cited.

The lead could use improvement. It should be a good, clear, and concise summary of the article. Ideally, 3 paragraphs. I would also try not to imply things in the lead; such as stating that hepatotoxicity, "implies chemical-driven liver damage." The very first sentence should define the topic of the article, specifically. See WP:LEAD for tips on improving the lead section.

The 1/2/3 headers under 'Drug metabolism in liver' are written kind of awkwardly. I'd recommend changing their formatting a bit, probably to 2nd level headers. Remove the numbering as well, as it's really not necessary to a good comprehension of the article.

The order and organization of sections should be reexamined to try and make the article flow better. The first two sections (metabolism and mechanisms) seem to make sense, but after that, sections seem to be just thrown together. The 'Specific drug or toxin' section reads like just a collection of examples of toxicity, and mostly examples of interest to random editors, and not very complete. The use of the image gallery for herbal and alternative remedies also places some extra emphasis on a very minor subset of drugs here.

These are the major issues with the article. Other issues could become more apparent as the article is worked on, so it's incomplete. But hopefully this will provide a good starting point for improvement. Cheers! Dr. Cash 20:38, 3 November 2007 (UTC)[reply]

Using ICD codes[edit]

doi:10.1111/j.1572-0241.2007.01456.x - ICD9 codes are not very useful in identifying cases of DILI. JFW | T@lk 23:03, 5 November 2007 (UTC)[reply]

doi:10.1111/j.1365-2036.2007.03307.x - 17 page review JFW | T@lk 20:14, 7 April 2008 (UTC)[reply]

Paracetamol / Acetaminophen[edit]

Should the equivalency of these two terms be mentioned / highlighted when discussing it in relation to hepatotoxicity? According to the page for paracetamol (redirected from the link to acetaminophen), most of the world uses 'paracetamol', so surely it should be at least mentioned, even if the article could continue to use 'acetaminophen' in the main. OJ —Preceding unsigned comment added by 86.158.55.184 (talk) 18:24, 9 April 2010 (UTC)[reply]

Ethanol[edit]

Um... isn't this the most notorious culprit for hepatoxicity? There are a few mentions of wanting to know one's alcohol intake, but no details on the effect of alcohol itself on the liver. Twin Bird (talk) 05:05, 1 May 2011 (UTC)[reply]

Yes, that's true. The article has a big lack of information on this. Alcoholic liver disease is the major cause of liver disease in Western countries. --Stefan Bach7777 (talk) 20:24, 25 November 2013 (UTC)[reply]

Nefazodone[edit]

Nefazodone was not removed from the market; it is still being dispensed! I would like to see the reference that supports this claim. — Preceding unsigned comment added by 66.189.98.111 (talk) 02:59, 16 December 2011 (UTC)[reply]

garcinia cambogia[edit]

the wiki on this herb / fruit suggests it may be hepatotoxic — Preceding unsigned comment added by 68.195.88.82 (talk) 03:00, 9 March 2013 (UTC)[reply]

Drug induced liver injury[edit]

"Drug induced liver injury" has over 24k references on Medline but WP has no entry. "Drug induced liver disease" redirects here. DILI is now a major diagnostic classification. Should we have a separate entry for DILI rather than a redirect? Jrfw51 (talk) 21:30, 8 October 2015 (UTC)[reply]

@Jrfw51: Depends whether it is distinct from hepatotoxicity, and which term is more common. JFW | T@lk 19:47, 14 May 2017 (UTC)[reply]

@Jfdwolff: Pubmed searches today: "drug induced liver injury" = 26668; "hepatotoxity" = 16232; "drug induced liver injury" not "hepatotoxicity" = 20392; "hepatotoxicity" not "drug induced liver injury" = 9956. What do you think? Jrfw51 (talk) 20:26, 17 May 2017 (UTC)[reply]

Review[edit]

doi:10.1136/gutjnl-2016-313369 JFW | T@lk 19:47, 14 May 2017 (UTC)[reply]