Talk:Herpes simplex virus

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Treatment[edit]

There should be a section on the treatments for the fever blisters 63.26.77.8 (talk) 22:19, 26 January 2009 (UTC)eric

The current page contents describing a patent for laser therapy should require more details or links to medical studies. The light therapy is purported to treat an unusually large number of physiological ailments... it sounds a little too optimistic and perhaps suspect of exaggeration.

The current page also listed comments describing that current HSV treatment involved the topical/oral/intravenous use of "chemotherapeutic agents". The language used gives the appearance of fear mongering (chemotherapy uses various gradations of necessary toxicity) and moreover is inaccurate by the simple example that HSV is also treated via antivirals, such as Acyclovir(spelling?) which are not chemotherapy medications in and of themselves.

I would like to put a flag suggesting more thorough review of the text currently written under the section "Treatment" of the HSV article. Neibwe (talk) 17:11, 27 June 2009 (UTC)

  • I have Been Bold and deleted this section, which as far as I can tell has no encyclopedic worth. I have a stub up now, but it desperately needs the attention of knowledgeable individuals who aren't trying to sell something. If you want to improve this article, I suggest reading previously deleted revisions and synthesizing a brief overview of treatment from that raw material. 173.66.253.109 (talk) 00:15, 6 July 2009 (UTC)

"Crudescent?"[edit]

From the article, "Lesions heal with a crudescent scab." What does crudescent mean? It's not in the dictionary at dictionary.com nor wiktionary nor Answers.com, and most Google results are simply variations on that phrase. 68.36.163.22 05:35, 17 August 2007 (UTC)

Proposed section merges/article deletion[edit]

The dual coverage of Herpes Simplex Virus (this article) vs. Herpes Simplex Disease, in addition to the article Herpesviridae, is not working out as well as I had hoped. I previously argued for the maintenance of two articles, one for the disease, the other for the virus -- similar to the two articles maintained for AIDS and HIV. However, in the case of Herpes, the similarity of naming is part of the difficulty in maintaining two independent articles.

Here is my view of this articles sections:

  • Intro
At present, this article's introductory material is largely repetitive of the information from the disease article, and should be merged to the disease article or deleted.
  • Life cycle
This information is true for all Herpes viruses and belongs in Herpesviridae.
  • Treatment
The information here that relates treatment mechanism to viral biology belongs in Herpesviridae. Epidemiological information belongs in Herpes Virus.
  • Vaccine
This little section should merge with the disease article.

I think the original intent of these two article will be better served if Herpes virus information is accumulated at the Herpesviridae article. The technical-sounding name there will discourage general disease information being added. I have added merge tags in the hope of generating discussion here.

ManVhv 01:02, 6 June 2007 (UTC)

I am usually a proponent of the "two-article" model you mention above: one for the causative/etiologic agent and a separate one for the disease (with, in this case, a third "genus-level" entry). I'm still in that camp, but I can see some of you concerns in this particular case. I think that we should give your proposal a shot—if it turns out to solve the problem, great. If not, we can always re-evaluate and try something else. Let me know if you want any help in the reconstruction phase. -- MarcoTolo 01:49, 12 June 2007 (UTC)


Vaccine Research[edit]

>>Previous studies have determined that this vaccine is approximately 70% effective in women, but does not prevent the disease in men. [22]

I have read material about Herpevac that states that the vaccine didn't offer HSV-2 protection to people who already had HSV-1 infection. I assume this means that someone who already has HSV-1 will have the same level of immunity to HSV-2 as a completely uninfected person who is given the vaccine. HSV-1 infection is very common. If someone could find some hard information on this it would be worth updating that section.

Your assumption is incorrect, and no section update is needed. It may be worth noting that the vaccine did not work well with HSV-1 infected patients, but it is absolutely wrong to suggest any "conclusion" about what that means for the immunity of people infected with HSV-1. As a matter of fact, there is copious research which indicates that HSV-1 infection has no helpful effect w.r.t. HSV-2 infection, just as Chicken Pox (HSV-3) also has nothing to do with it. ManVhv 19:30, 15 August 2007 (UTC)

Talk prior to 5 June moved to Archive[edit]

I have moved talk prior to 5 June 2007 to this archive.

ManVhv 00:57, 6 June 2007 (UTC)

Symptoms[edit]

Could someone please add more details on symptoms of HSV 1 and 2? There isn't much discussion of what the symptoms are like. —Preceding unsigned comment added by 71.130.209.38 (talk) 22:07, August 24, 2007 (UTC)

Symptoms[edit]

Could someone please add more details on symptoms of HSV 1 and 2? There isn't much discussion of what the symptoms are like. 71.130.209.38 22:11, 24 August 2007 (UTC)

During an outbreak the experience is itching more so the feet, legs and buttocks, like pins being jabbed into your feet, also your feet may feel extremely cold and numb at times. You feel as though worms are crawling under your skin. If you have bad dandruff check your scalp for pimple like lesions and a very irritable itchy scalp that will drive you nuts. A break out will cause hive like symptoms which look like blisters or lumps deep under the skin trying to break out. You may experience sharp pains through your body in the neck back and legs. Check your gums and roof of your mouth for sores that may look like warts and also check for ulcers. You may experience sharp stinging pain inside the eyes from the retina. Burning sensations, and heat behind the knees and aching joints. Tingling numbness in parts of your body. Fevers and head aches. Your ear lobes and ears can become dry and skin peel off over several days becoming sensitive to touch. you may experience tiny little blood blisters on your chest and stomach and also pimple type lesions on your arms and other parts of your body. Check your genitals for redness and tiny little warts. An itchy anus can be a sign —Preceding unsigned comment added by 58.167.229.202 (talk) 05:39, 5 July 2008 (UTC)

Could someone please add a section on HSV tests? Which ones are available and their accuracy? —Preceding unsigned comment added by 24.215.198.79 (talk) 01:25, 26 November 2007 (UTC)

Alzheimer's disease and HSV1[edit]

i am wondering why does it say to see alzheimer's disease? what is the connection between the two? (Dachronic215 22:33, 7 November 2007 (UTC))

There is no connection and I have deleted it.GrahamColm(Talk ) 18:17, 25 November 2007 (UTC)

There has been speculation and some research to suggest they may be a link since before 1983 (as far back as PubMed would locate a hit - see PMID 6308942). Recent papers hinting a link are PMID 16242250 & PMID 16463223. But as an old paper (PMID 15319093) points out, association has not been proof of cause (vs effect of Alzheimer plaques perhaps encouraging HSV). Still it remains topical - see NetDoctor report Alzheimer's disease may be linked to cold sore virus from 1st Nov'07 (although PubMed does not seem to list any newly published material by Itzhaki, the lead researcher mentioned, since Jan'07). David Ruben Talk 19:20, 25 November 2007 (UTC)
The link to alzheimer's disease should be reinstated, since the link between the two is now in the mainstream media [1]. This should be expanded in the text. Fig (talk) 12:02, 8 December 2008 (UTC)


see: http://www.polygenicpathways.co.uk/herpalz.htm —Preceding unsigned comment added by 174.88.19.146 (talk) 19:35, 7 January 2011 (UTC)

Some other articles:
1) Antiviral Drugs May Slow Alzheimer's Progression
http://www.sciencedaily.com/releases/2011/10/111017102557.htm
2) Wozniak MA, Frost AL, Preston CM, Itzhaki RF (2011) Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1. PLoS ONE 6(10): e25152. doi:10.1371/journal.pone.0025152
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025152
Zarkme (talk) 07:23, 16 September 2013 (UTC)

HSV genome link?[edit]

In some of the external links, also on what google brings up, there are statements like 'the full genome of HSV 1/2 is known'. Any URL anyone? —Preceding unsigned comment added by 217.80.81.221 (talk) 04:51, 22 December 2007 (UTC)

"excema"[edit]

The proper spelling of the skin condition characterized by itchy, irritated, inflamed skin is "eczema" [1].

There is no word in the English language (UK English or US English) spelled "excema". I have corrected this in the main article.

I would also like to see a citation or two that eczema can cause herpes to flare up.

Networkprosource (talk) 18:07, 7 March 2008 (UTC)

Oral/Genital infection rates[edit]

The statistics only show HSV-1 and HSV-2 infection rates, not the location as to what's infected. Klosterdev (talk) 03:05, 2 April 2008 (UTC) Edit: Whoop, my bad, wrong article. Klosterdev (talk) 03:06, 2 April 2008 (UTC)

how are HIV and HSV related?[edit]

my wife was told by the doctor that she came in contact with HIV which is what caused the HSV. is this true? what is the connection between the two? —Preceding unsigned comment added by Iamscared (talkcontribs) 17:25, 15 July 2008 (UTC)

Perhaps she heard 'caused in the same way' which is sexual transmission. HIV is quite different. Not even close. Minor research will show you that fact. — Preceding unsigned comment added by 184.148.34.171 (talk) 03:10, 13 August 2012 (UTC)

Infected?[edit]

How can I find out if I am infected with Herpes? I've never had an outbreak so I wouldn't know. —Preceding unsigned comment added by 86.121.67.118 (talk) 14:28, 28 January 2009 (UTC)

Lesser known Herpes site[edit]

You should include that in rare cases the Herpes virus can attack the eyes, and the watery blisters associated with cold sores or oral Herpes can appear on the upper and lower eyelids as well as high on the cheeks. In extremely rare cases, the blisters can actually form on the eyeball.

Also, I have been infected with Herpes Simlex 1 my entire life (that's how I know about the eyes because that's where I break out) and I have not experienced many of the symptoms listed above in the second "symptoms" section, so I would like to clarify that the most common symptoms (for simplex 1, at least)consist of a tingling, sometimes burning sensation at the site of the breakout, followed by itching (don't scratch or you'll spread it!) and a feeling of fullness. Within an hour of the start of the itching, small blisters will form. If left untreated, these blisters will spread and/or leak clear fluid containing the virus before scabbing over. If you begin treatment at the tingling stage, there's a chance you can stop the outbreak before the blisters form. —Preceding unsigned comment added by 132.3.9.68 (talk) 02:52, 19 May 2009 (UTC)

Symptoms[edit]

I can honestly say that being an individual who suffers from HSV-2 that they Sympotoms described before my addition to this topic are rather different. When people ask me to desribe what it feels like or more like what I feel during an outbreak, I have described it in a very different way. Also please don't think that what I am about to say is what every person who suffers from this virus experiences, not by far. But this is what myself and others that I have spoken with endure during an outbreak. Imagine a bad case of Chicken Pox or you have accidently walked through a patch of Poison Oak, now instead of the rash being on your arms, legs, chest or mid-section it is on your genital area. It is a constant uncomfortable itching and burning that you are unable to scratch. When you do scratch it will relieve the sensation only while you are doing it but as soon as you stop it only seems to be that much more intense. I have lived with this for 14 years now and I have found that if I do scratch and if I pop a legion/blister and touch another surface in the general area where the skin is already broken then the next time that I have an outbreak I am much more likely to have a legion/blister appear during the next outbreak. Also, another thing that others an myself have found that it seems like the more stress that I am under cause either an outbreak or if I am already having an outbreak an increase in the severity and/or duration of the current outbreak. I would like to hear if others who stumble across this discussion and suffer from this virus if s/he experience the same things myself and others have. —Preceding unsigned comment added by Hosbeck1981 (talkcontribs) 12:06, 5 July 2010 (UTC)

Please note that Wikipedia is not a forum for general discussion. Graham Colm (talk) 18:16, 5 July 2010 (UTC)

lytic[edit]

I was interested in whether hsv-2 became lytic and destroyed the nerve cells. Normally it is latent and actually helps maintain the cell. The statement; "Research using flow cytometry on another member of the herpes virus family, Kaposi's sarcoma-associated herpesvirus, indicates the possibility of an additional lytic stage, delayed-late.[20]" only states an implication that a lytic stage is possible because it occurs in another member of the family. The following reference indicates that a lytic stage is known and studied. "We examined HSV-1 during lytic infection using micrococcal nuclease digestion and chromatin immunoprecipitation." http://jvi.asm.org/cgi/content/full/78/18/10178 —Preceding unsigned comment added by 174.88.19.146 (talk) 18:21, 7 January 2011 (UTC)

garlic[edit]

  • In the current stub treatment section, there is a mention of using garlic on erupting lesions. The study that is referenced for this statement doesn't exist. Can the person who posted that reference please revise it or else remove that line? I'll also note that even if there is a single small study that shows the efficacy of garlic (which I doubt), it is certainly not in widespread use and is not an accepted treatment. — Preceding unsigned comment added by 99.230.244.133 (talk) 20:12, 15 August 2011 (UTC)
I have fixed the reference but I have hidden the statement, pending verification. The reference can be seen in edit mode. Graham Colm (talk) 20:50, 15 August 2011 (UTC)
And below:

Weber ND, Andersen DO, North JA, Murray BK, Lawson LD, Hughes BG (October 1992). "In vitro virucidal effects of Allium sativum (garlic) extract and compounds". Planta Medica 58 (5): 417–23. doi:10.1055/s-2006-961504. PMID 1470664.  Graham Colm (talk) 20:54, 15 August 2011 (UTC)

--section that was commented out (and breaking layout) start-- For cold sores of the lips and mouth area, rubbing a cut clove of raw garlic on a suspect area as soon as the "itching and tingling" occur may prove effective in stopping an outbreak.[2] --section that was commented out (and breaking layout) end--

References[edit]

Should this be included? Rich Farmbrough, 21:49, 16 September 2012 (UTC).