Talk:Indoleamine 2,3-dioxygenase

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EC wrong[edit]

This is, in fact, EC 1.13.11.52 not 42. --Ayacop (talk) 18:38, 31 December 2008 (UTC)[reply]

Should mention two isoforms inc IDO2[edit]

Should mention two isoforms and clarify if IDO2 from same or different gene. Also Epacadostat and BMS-986205 are selective inhibitors of IDO1 [1]. Indoximod inhibits IDO2. - Rod57 (talk) 31 August 2017‎

IDO is only active in a low-oxygen (hypoxic) environment.[edit]

"IDO is only active in a low-oxygen (hypoxic) environment." says [2] - Rod57 (talk) 19:43, 25 November 2017 (UTC)[reply]

Could expand IDO inhibitors for cancer[edit]

Discussion of mixed results of clinical trials in [3]. Ideally find a better source with refs. IDO inibitors could usefully be a separate article because of multiple enzymes targeted. - Rod57 (talk) 08:21, 7 June 2018 (UTC)[reply]

further reading[edit]

moving this here. this is excessive.

Further reading

Grohmann U, Fallarino F, Puccetti P (May 2003). "Tolerance, DCs and tryptophan: much ado about IDO". Trends in Immunology. 24 (5): 242–8. doi:10.1016/S1471-4906(03)00072-3. PMID 12738417.
Takikawa O (December 2005). "Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated L-tryptophan metabolism". Biochemical and Biophysical Research Communications. 338 (1): 12–9. doi:10.1016/j.bbrc.2005.09.032. PMID 16176799.
Puccetti P (April 2007). "On watching the watchers: IDO and type I/II IFN". European Journal of Immunology. 37 (4): 876–9. doi:10.1002/eji.200737184. PMID 17393386.
Kadoya A, Tone S, Maeda H, Minatogawa Y, Kido R (November 1992). "Gene structure of human indoleamine 2,3-dioxygenase". Biochemical and Biophysical Research Communications. 189 (1): 530–6. doi:10.1016/0006-291X(92)91590-M. PMID 1449503.
Kamimura S, Eguchi K, Yonezawa M, Sekiba K (June 1991). "Localization and developmental change of indoleamine 2,3-dioxygenase activity in the human placenta". Acta Medica Okayama. 45 (3): 135–9. PMID 1716396.
Tone S, Takikawa O, Habara-Ohkubo A, Kadoya A, Yoshida R, Kido R (January 1990). "Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA". Nucleic Acids Research. 18 (2): 367. doi:10.1093/nar/18.2.367. PMC 330282. PMID 2326172.
Werner-Felmayer G, Werner ER, Fuchs D, Hausen A, Reibnegger G, Wachter H (September 1989). "Tumour necrosis factor-alpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells". Biological Chemistry Hoppe-Seyler. 370 (9): 1063–9. doi:10.1515/bchm3.1989.370.2.1063. PMID 2482041.
Carlin JM, Borden EC, Byrne GI (June 1989). "Interferon-induced indoleamine 2,3-dioxygenase activity inhibits Chlamydia psittaci replication in human macrophages". Journal of Interferon Research. 9 (3): 329–37. doi:10.1089/jir.1989.9.329. PMID 2501398.
Kobayashi K, Hayashi K, Sono M (September 1989). "Effects of tryptophan and pH on the kinetics of superoxide radical binding to indoleamine 2,3-dioxygenase studied by pulse radiolysis". The Journal of Biological Chemistry. 264 (26): 15280–3. PMID 2549057.
Daley-Yates PT, Powell AP, Smith LL (November 1988). "Pulmonary indoleamine 2,3-dioxygenase activity and its significance in the response of rats, mice, and rabbits to oxidative stress". Toxicology and Applied Pharmacology. 96 (2): 222–32. doi:10.1016/0041-008X(88)90082-8. PMID 2848333.
Burkin DJ, Kimbro KS, Barr BL, Jones C, Taylor MW, Gupta SL (July 1993). "Localization of the human indoleamine 2,3-dioxygenase (IDO) gene to the pericentromeric region of human chromosome 8". Genomics. 17 (1): 262–3. doi:10.1006/geno.1993.1319. PMID 8406467.
Malina HZ, Martin XD (July 1996). "Indoleamine 2,3-dioxygenase: antioxidant enzyme in the human eye". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. 234 (7): 457–62. doi:10.1007/BF02539413. PMID 8817290.
Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, Brown C, Mellor AL (August 1998). "Prevention of allogeneic fetal rejection by tryptophan catabolism". Science. 281 (5380): 1191–3. doi:10.1126/science.281.5380.1191. PMID 9712583.
Takikawa O, Littlejohn TK, Truscott RJ (March 2001). "Indoleamine 2,3-dioxygenase in the human lens, the first enzyme in the synthesis of UV filters". Experimental Eye Research. 72 (3): 271–7. doi:10.1006/exer.2000.0951. PMID 11180976.
Kudo Y, Boyd CA (March 2001). "The role of L-tryptophan transport in L-tryptophan degradation by indoleamine 2,3-dioxygenase in human placental explants". The Journal of Physiology. 531 (Pt 2): 417–23. doi:10.1111/j.1469-7793.2001.0417i.x. PMC 2278460. PMID 11230514.
Papadopoulou ND, Mewies M, McLean KJ, Seward HE, Svistunenko DA, Munro AW, Raven EL (November 2005). "Redox and spectroscopic properties of human indoleamine 2,3-dioxygenase and a His303Ala variant: implications for catalysis". Biochemistry. 44 (43): 14318–28. doi:10.1021/bi0513958. PMID 16245948.
Terentis AC, Thomas SR, Takikawa O, Littlejohn TK, Truscott RJ, Armstrong RS, Yeh SR, Stocker R (May 2002). "The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions". The Journal of Biological Chemistry. 277 (18): 15788–94. doi:10.1074/jbc.M200457200. PMID 11867636.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Kvirkvelia N, Vojnovic I, Warner TD, Athie-Morales V, Free P, Rayment N, Chain BM, Rademacher TW, Lund T, Roitt IM, Delves PJ (February 2002). "Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells". Clinical and Experimental Immunology. 127 (2): 263–9. doi:10.1046/j.1365-2249.2002.01718.x. PMC 1906325. PMID 11876748.
Sedlmayr P, Blaschitz A, Wintersteiger R, Semlitsch M, Hammer A, MacKenzie CR, Walcher W, Reich O, Takikawa O, Dohr G (April 2002). "Localization of indoleamine 2,3-dioxygenase in human female reproductive organs and the placenta". Molecular Human Reproduction. 8 (4): 385–91. doi:10.1093/molehr/8.4.385. PMID 11912287.
Basran J, Efimov I, Chauhan N, Thackray SJ, Krupa JL, Eaton G, Griffith GA, Mowat CG, Handa S, Raven EL (October 2011). "The mechanism of formation of N-formylkynurenine by heme dioxygenases". Journal of the American Chemical Society. 133 (40): 16251–7. doi:10.1021/ja207066z. PMC 3210546. PMID 21892828.

-- Jytdog (talk) 02:12, 10 October 2018 (UTC)[reply]