|Ideal sources for Wikipedia's medical content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Isoflurane.
|WikiProject Pharmacology||(Rated Start-class, High-importance)|
Isoflurane is implicated in causing Alzheimers. See the related articles:
http://www.delnor.com/blank.cfm?print=yes&id=154&action=detail&ref=17193 Anesthetic Linked to Alzheimer's Risk
http://www.medpagetoday.com/Neurology/AlzheimersDisease/tb/5008 Cell Culture Experiments Link Florane to Dementia
http://www.rxpgnews.com/alzheimersdisease/isoflurane-may-set-off-a-process_printer.shtml Alzheimer's Isoflurane may produce Alzheimer's-like changes in the brain By Massachusetts General Hospital, Feb 8, 2007 - 3:56:30 AM
There are many other articles that support this research. Please add to this list, along with your comments and personal experience.
- When talking about science "Cause" is a very big word. When you say "there are many other articles that support this research", probably you are not really aware what a primary font is. The links that you gave are just from some news websites, and they all refer to the same study.
- That isoflurane *may* increase the risk of Alzheimer is still very debatable.
- 1) When looking at properly peer-reviewed articles (i.e. not just news site, but for instance by searching Pubmed) you will see that a query "isoflurane alzheimer" only returns 18 articles most of which do not refer to isoflurane causing Alzheimer's.
- 2) There are only 2 main articles that "prove" the link: they are from one single group, and the study have been made on cell cultures, not in vivo.
- 3) In a real situation is a) very unlikely that a person would be exposed to the same doses of isoflurane for so long (6h) and b) very unlikely that this exposition would be continued in time.
- So, definitely I would not say it is so indispensable to add that to the article. Gould80 (talk) 15:15, 11 June 2010 (UTC)
The article claims that isoflurane has an analgesic effect without citing any source. This is very disputed (e.g. a study that claims the opposite: http://bja.oxfordjournals.org/content/75/1/55.short), in general inhalational anaesthetics are not considered to be analgesic.
- The article you link specifies "subanaesthetic" concentrations. But other reports indicate that in the concentrations used for anesthesia, there is also an analgesic effect. See for example: Improved postoperative analgesia with isoflurane than with propofol anaesthesia. -- Ed (Edgar181) 13:25, 30 August 2011 (UTC)
The following list of references was added to the article, but they were not used to support specific content in the article. So I am moving them here in case anyone wants to use them to improve this article. -- Ed (Edgar181) 13:28, 30 August 2011 (UTC)
- Bigger sized anesthetics may be better Scientific American Mind 7 April 2007
- Anesthetics and Alzheimer disease probed JAMA April 23, 2007
- Pravat K. Mandal*, J. W. Pettegrew,” Abeta Peptide interactions with Isoflurane, Propofol, Thiopental and combined Thiopental with Halothane: A NMR Study” Biochemica Biophysica Acta, Biomembrane, (1778: 2633-2639 , 2008).
- Pravat K. Mandal*, J. W. Pettegrew,” Clinically relevant concentration determination of inhaled anesthetics (halothane, soflurane, sevoflurane and desflurane) by 19F NMR” Cell Biochemistry and Biophysics, (52:31-35, 2008)
- Pravat K. Mandal* and Vincenzo Fodale :" Smaller molecular-sized anaesthetics oligomerize Abeta peptide simulating Alzheimer’s disease: a relevant issue" European Journal of Anesthesiology, Vol 26(10) Page 805-806 , 2009 - Editorial
- Pravat K. Mandal*, Daniela Schifilliti, Federica Mafrica, and Vincenzo Fodale "Inhaled Anesthetics and Cognitive Performance" Drugs of Today, (45: 47-54, 2009).
- Pravat K Mandal*, Vincenzo Fodale "Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: An NMR study" Biochemical and Biophysical Research Communications. (379: 716-720, 2009)
- Pravat K Mandal*, Virgil Simplaceanu and Vincenzo Fodale : "Intravenous Anesthetic Diazepam does not induce Amyloid beta-peptide Oligomerization but Diazepam Co-administered with Halothane Oligomerizes Amyloid Beta-peptide: An NMR study" Journal of Alzheimer Disease April, 2010
- V. Fodale, L.B. Santamaria, D. Schifilliti and P. K. Mandal : "Anaesthetics and post-operative cognitive dysfunction: a pathological mechanism mimicking Alzheimer’s Disease" Anesthesia Journal (Vol 65(4) page 388-395, April 2010)
- Juan Perucho1, Isabel Rubio2, Maria J. Casarejos1, Ana Gomez1, Jose A. Rodriguez-Navarro1, Rosa M. Solano1, Justo Garcia De Yébenes2, Maria A. Mena1 Anesthesia with Isoflurane Increases Amyloid Pathology in Mice Models of Alzheimer'S Disease, Journal of Alzheimer Disease, March 2010