Talk:Melanocortin 1 receptor

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Mc1r v. MC1R[edit]

Subject line says it all - this article uses Mc1r, but some of the references at least use MC1R - which is correct? Rachel Pearce (talk) 11:32, 26 February 2008 (UTC)


Genetics image[edit]

I have removed the image of the map of human skin colours over the globe as it is misleading and irrelevant to the topic (we're discussing the 1-4% of the population with a dysfunctional MC1R variation, not the evolution of skin colour in the general population).

There is however a more relevant image of the distribution of red hair in the United Kingdom at http://anthro.palomar.edu/vary/images/map_of_red_hair_in_England.gif (the HTML it's used in is http://anthro.palomar.edu/vary/vary_1.htm) that maybe should go in its place. The image is "reproduced with permission from Cambridge University Press. From E. Sunderland, "Hair-Colour in the United Kingdom," The Annals of Human Genetics, Vol. 20, p. 327, 1955-56", the original article can be found here: http://onlinelibrary.wiley.com/doi/10.1111/j.1469-1809.1955.tb01286.x/abstract but you have to pay to see the whole thing.

Can someone either get permission and upload it, or tell me how to go about it. Tobus2 (talk) 01:09, 26 January 2011 (UTC)

Dental pain in humans[edit]

I believe the prevalence of people with MC1R who have a GREAT deal of pain during dental procedures is relevant to this article (apparently it confers immunity to anesthetic).

http://jada.ada.org/content/140/7/896.abstract http://articles.cnn.com/2009-07-30/health/redhead.pain.dentist_1_red-hair-thermal-pain-redheads?_s=PM:HEALTH http://en.wikipedia.org/wiki/Outcomes_Research_Consortium#Red_Hair_and_Anesthesia — Preceding unsigned comment added by Dianaramadani (talkcontribs) 09:40, 20 January 2012 (UTC)

Red hair and freckles[edit]

The last part in the function section says "People with freckles and no red hair, have an 85 percent chance of carrying the defective MC1R gene that is connected to red hair, and the red hair gene. People with no freckles and no red hair have an 18 percent chance of carrying the defective MC1R gene linked to red hair." Granted, citations are needed for these statements, but what are the percentages of carrying the gene with both red hair and freckles? — Preceding unsigned comment added by 67.142.172.21 (talk) 18:48, 9 May 2012 (UTC)