MER receptor tyrosine kinase
MERis a cell surface receptor belonging to the TAM family to tyrosine kinases. The two other members comprising this group are Tyro-3 and AXL.
Structure Mer, Axl, and Tyro-3 all share similar structures in that the extracellular domain contains a pair of FNIII (fibronectin type 3) and Ig-like regions. There is a transmembrane, and an intracellular region. The intracellular region contains tyrosine residues which become phosporylated upon activation with its ligand.
Ligands Thus far, two molecules have been identified and confirmed to activate TAM: one of them being growth-arrest-specific gene 6 (Gas 6) and Protein S.
Relevance in Cancer Of the three members of the TAM family, AXL and MER are the most studied. MER and AXL appear in some normal tissue however in many cancers MER and AXL are over-expressed. —Preceding unsigned comment added by 188.8.131.52 (talk) 22:24, 17 February 2010 (UTC)