Talk:Molecular pathological epidemiology

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2nd lead[edit]

I have moved the second lead from the mainpage to the talkpage. Either one is fine, but they shouldn't both be on the page.AioftheStorm (talk) 22:18, 9 February 2014 (UTC)


Molecular pathological epidemiology[edit]

Molecular Pathological Epidemiology (also described as “Molecular Pathologic Epidemiology”; abbreviated as MPE) is an emerging discipline within epidemiology. It is defined as epidemiology of molecular pathology and heterogeneity of disease. As the name implies, MPE represents an interdisciplinary integration of “molecular pathology” and “epidemiology”. As advancement of biotechnology has become rapid since 2000s, disease subtyping by molecular methods has become routine clinical practice and an application of molecular pathology to epidemiology is increasingly widespread.[1][2][3][4] A better understanding of heterogeneity of disease pathogenesis and evolution contributes to elucidation of etiologies of diseases. The MPE approach has become increasingly common in 2010s.[5][6][7][8][9][10][11][12][13]

  1. ^ Ogino S, Stampfer M. Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology. J Natl Cancer Inst 2010; 102: 365-7
  2. ^ Jacobs RJ, Voorneveld PW, Kodach LL, Hardwick JC. Cholesterol metabolism and colorectal cancers. Curr Opin Pharmacol 2012;12: 690-5. doi: 10.1016/j.coph.2012.07.010
  3. ^ Begg CB, Zabor EC. Detecting and exploiting etiologic heterogeneity in epidemiologic studies. Am J Epidemiol 2012;176: 512-8.
  4. ^ Kuller LH. Invited commentary: the 21st century epidemiologist--a need for different training? Am J Epidemiol 2012; 176: 668-71. doi: 10.1093/aje/kws227.
  5. ^ Curtin K, Slattery ML, Samowitz WS. CpG island methylation in colorectal cancer: past, present and future. Pathology Research International 2011; 2011: 902674.
  6. ^ Hughes LA, Khalid-de Bakker CA, Smits KM, van den Brandt PA, Jonkers D, Ahuja N, Herman JG, Weijenberg MP, van Engeland M. The CpG island methylator phenotype in colorectal cancer: Progress and problems. Biochim Biophys Acta 2012; 1825: 77-85.
  7. ^ Chia WK, Ali R, Toh HC. Aspirin as adjuvant therapy for colorectal cancer-reinterpreting paradigms. Nat Rev Clin Oncol 2012; 9: 561-70.
  8. ^ Galon J, et al. Cancer classification using the Immunoscore: a worldwide task force. Journal of Translational Medicine 2012; 10: 205.
  9. ^ Rex DK, et al. Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol 2012; 107: 1315-29.
  10. ^ Spitz MR, Caporaso NE, Sellers TA. Integrative cancer epidemiology--the next generation. Cancer Discov 2012; 2: 1087-90.
  11. ^ Zaidi N, Lupien L, Kuemmerle NB, Kinlaw WB, Swinnen JV, Smans K. Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids. Prog Lipid Res 2013; 52: 585-9.
  12. ^ Field AE, et al. The merits of subtyping obestity: one size does not fit all. JAMA 2013; 310: 2147-8.
  13. ^ Ikramuddin S, Livingston EH. New Insights on Bariatric Surgery Outcomes. JAMA 2013; 310: 2401-2.

Sources[edit]

This article is still using far too many primary sources. Per wp:MEDRS, Wikipedia articles should be beaded on secondary sources! such as peer-reviewed review papers or textbooks. Please seek out such sources, rather than ones authored by the researchers themselves. LeadSongDog come howl! 22:16, 2 March 2014 (UTC)

agreed 100%. this page is hinky, as are the related ones made by the same users. Jytdog (talk) 22:27, 2 March 2014 (UTC)

Essay, WP:OR[edit]

This article is basically an essay and needs to be re-written in encyclopedic style. One thing that is grating on me, is the promotional statement that "the MPE paradigm has been globally adopted and in widespread use" following by what used to be about 20 examples of primary sources that some editors claim are examples of researc using the paradigm. This is the definition of original research. What we need, is one or two review articles, which actually say that the MPE paradigm has been globally adopted and in widespread use. Making the claim, and supporting it with examples you dig up is not valid in Wikipedia - it violates the policy, "original research". I have tagged the article and will be working to clean this up over the next week or so. Jytdog (talk) 14:51, 25 August 2014 (UTC)

Querying pubmed for

("review"[Publication Type] OR "review literature as topic"[MeSH Terms] OR "review"[All Fields]) AND "Molecular pathological epidemiology"[All Fields] AND (Review[ptyp] AND "2009/08/30"[PDat] : "2014/08/28"[PDat])

finds seven papers, five of which are by Ogino et al. The other two are PMID 22056543 and PMID 22884562, with rather peripheral focus on MPE. Are there other reviews on which to draw? LeadSongDog come howl! 02:05, 29 August 2014 (UTC)