Talk:NMDA receptor

From Wikipedia, the free encyclopedia
Jump to: navigation, search
          This article is of interest to the following WikiProjects:
WikiProject Molecular and Cellular Biology (Rated B-class, Mid-importance)
WikiProject icon This article is within the scope of the WikiProject Molecular and Cellular Biology. To participate, visit the WikiProject for more information.
B-Class article B  This article has been rated as B-Class on the project's quality scale.
 Mid  This article has been rated as Mid-importance on the project's importance scale.
 
WikiProject Neuroscience (Rated C-class, High-importance)
WikiProject icon This article is within the scope of WikiProject Neuroscience, a collaborative effort to improve the coverage of Neuroscience on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.
C-Class article C  This article has been rated as C-Class on the project's quality scale.
 High  This article has been rated as High-importance on the project's importance scale.
 
WikiProject Biophysics (Rated B-class, Mid-importance)
WikiProject icon This article is within the scope of WikiProject Biophysics, a collaborative effort to improve the coverage of Biophysics on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.
B-Class article B  This article has been rated as B-Class on the project's quality scale.
 Mid  This article has been rated as Mid-importance on the project's importance scale.
 
Note icon
This article has been automatically rated by a bot or other tool because one or more other projects use this class. Please ensure the assessment is correct before removing the |auto= parameter.


Untitled[edit]

I don't have time to do this now, but someone should change all of the NR1/NR2 to GluN1/GluN2. This is now the preferred denotation that is used in the literature. It keeps the format of the subunit name consistent with other glutamate receptors(for example AMPA subunits are GluA1/2 (which used to be GluR1/2) and Kinate subunits are GluK...) 18 February 2012 — Preceding unsigned comment added by 140.160.61.201 (talk) 20:49, 18 February 2013 (UTC)

I think it could be useful to have a section with examples of cell types that display particular kinds of receptors, both in the NMDA and in the AMPA pages.MNegrello (talk) 07:50, 22 February 2010 (UTC)

There is a nr3a/b subunit for example see: Subunit-specific Roles of Gycine-Binding Domains in Activation of NR1/NR3 "NMDA" Receptors —Preceding unsigned comment added by 141.5.4.128 (talk) 14:13, 16 April 2008 (UTC) Can someone post the list of agonists for NMDA receptors including D-serine, cycloserine and sarcosine. —Preceding unsigned comment added by 76.122.99.157 (talk) 15:05, 13 February 2010 (UTC)

i thougt there was even a n3 subunit...but i cant recall where i read it

The structure section was misleading and out of date. The multimeric NMDA receptor protein contains four subunits, although once it was thought that five subunits were present, as for a muscle nicotinic receptor. However, glutamate receptors are more closely related to potassium channels and share their tetrameric arrangment. These subunits are the products of up to 8 different genes. It is a nice idea to mention structural features of the protein, which is why I added the part about the ligand binding domain. I think that this page needs more updating, and so I will proceed with caution and make a few changes Aplested 13:31, 22 Sep 2004 (UTC)

Most of this article is lifted from the abstract of the Liu and Yang paper in the external link section. Not really well known or quoted, certainly not a patch on the Dingledine review, which has the benefit of being freely available. Aplested 13:51, 22 Sep 2004 (UTC)

Just added a link to the Long-term potentiation thought that it is quite relevant. -- Amelvin 22:40, 13 May 2006 (UTC)

I've been studying receptors and I haven't found any info on wiki about PCP receptors. I read at http://www.esi-topics.com/schizophrenia/interviews/Dr-Daniel-Javitt.html that PCP receptars are a part of NMDA receptors. I think that should be mentioned in this article and searches for PCP receptors should link here. Eddietoran 05:51, 13 October 2006 (UTC)

Although PCP is an NMDA receptor antagonist (PCP makes the receptor unable to activate) it also binds to D2 dopamine receptors and 5-HT2 serotonin receptors. Pages that discuss PCP should then link to the pages of these receptors. Sciencepixie 17:36, 14 March 2007 (UTC)

Reference: Molecular Psychiatry 2002, Volume 7, Number 8, Pages 837-844

In the antagonists list, please add Magnesium ion (Mg2+)

Methadone is in the 'dual opioids and NMDA antagonists' list, but that is because methadone is a stereomere (sp?), the l-form is an opioid, while d-methadone is an NMDA antagonist. So it's more properly the racemic mixture that is both. — Preceding unsigned comment added by 87.211.115.30 (talk) 14:33, 1 June 2012 (UTC)

We might want to add a section on the functional significance of NMDAR's? E.g. working memory. FlinZ (talk) 13:11, 11 February 2013 (UTC)