Talk:Paternal age effect
|WikiProject Medicine / Reproductive medicine||(Rated C-class, Low-importance)|
- It really needs to be peer-reviewed research which has been published in a reputable scientific journal. See Wikipedia:No original research. -Fsotrain09 17:31, 27 December 2006 (UTC)
Large parts of this page are copied/pasted from this link: http://www.uthscsa.edu/opa/issues/new33-32/graduate.htm
Article claims that at least one X-linked condition is influenced by paternal age; no source cited for this questionable claim. —Preceding unsigned comment added by 126.96.36.199 (talk) 23:48, 2 August 2008 (UTC)
as far as i can tell, hemophilia is a genetic disorder that's inherited through two recessive genes. How the age of the father affects this, i don't know. How would his age affect a gene he had in his DNA from birth? —Preceding unsigned comment added by 188.8.131.52 (talk) 19:55, 27 August 2008 (UTC)
|This article is currently or was the subject of an educational assignment.|
- MedicineNet.com lists two types of paternal age effects. The two types are autosomalmutations and an indirect paternal age effect from mutations on the X chromosome.  
- MedicineNet.com also states that there is no universal definition of advanced paternal age, but does suggest that in the realm of genetic counseling, all men 40 yrs and older at the time of conception meet the criterion.
- Commenting on the study of 78 Icelandic families, Harry Fisch, MD, clinical professor of urology and reproductive medicine at Weill Cornell Medical College of Cornell University, suggests that now men too have a reference point in decisions of advanced paternal age and risk for genetic defects.The article cites that for women the age of 35 is a benchmark in determining the age of increasing escalation of genetic defect risks and that now men can assume a doubling of the mutation rate every 16 years.
- Definition of advanced paternal age.
- Autism Risk Across Generations.
- Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G, Gudjonsson SA, Sigurdsson A, Jonasdottir A, Jonasdottir A, Wong WS, Sigurdsson G, Walters GB, Steinberg S, Helgason H, Thorleifsson G, Gudbjartsson DF, Helgason A, Magnusson OT, Thorsteinsdottir U, Stefansson K (2012). "Rate of de novo mutations and the importance of father's age to disease risk". Nature 488 (7412): 471–5. doi:10.1038/nature11396. PMC 3548427. PMID 22914163.
- Father's Age Linked to Autism.
In the History section of the article, a more developed history of how the Paternal Age Effect was discovered, came about could be included. In the Notable Conditions and Diseases section, many diseases are listed at the bottom without explanation. If enough information is available, more common conditions and diseases should be elaborated on, namely cataracts, heart defects, hemophilia, Klinefelter's Syndrome. Go more in-depth in the Semen & Sperm Abnormalities section, taking more about the actual studies that were preformed and the results they had. Also include aneuploidy as potential abnormality.