Talk:Paternal age effect

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Paternal Age[edit]

Is there any part of the paternal age effect that belongs in Wikipedia? —Preceding unsigned comment added by Anniepema (talkcontribs)

It really needs to be peer-reviewed research which has been published in a reputable scientific journal. See Wikipedia:No original research. -Fsotrain09 17:31, 27 December 2006 (UTC)

Large parts of this page are copied/pasted from this link:

Article claims that at least one X-linked condition is influenced by paternal age; no source cited for this questionable claim. —Preceding unsigned comment added by (talk) 23:48, 2 August 2008 (UTC)


as far as i can tell, hemophilia is a genetic disorder that's inherited through two recessive genes. How the age of the father affects this, i don't know. How would his age affect a gene he had in his DNA from birth? —Preceding unsigned comment added by (talk) 19:55, 27 August 2008 (UTC)

de novo mutations increase with advancing paternal age —Preceding unsigned comment added by (talk) 03:13, 22 October 2009 (UTC)

Neutral tone[edit]

The tone of this article is strange for a medical article. Something like this "If my son or daughter was to ask..." isn't very scientific. Bhny (talk) 20:26, 24 December 2013 (UTC)


Definition lists two types of paternal age effects. The two types are autosomalmutations and an indirect paternal age effect from mutations on the X chromosome. [1] [2]

Clinical implications also states that there is no universal definition of advanced paternal age, but does suggest that in the realm of genetic counseling, all men 40 yrs and older at the time of conception meet the criterion.[1]


Commenting on the study of 78 Icelandic families,[3] Harry Fisch, MD, clinical professor of urology and reproductive medicine at Weill Cornell Medical College of Cornell University, suggests that now men too have a reference point in decisions of advanced paternal age and risk for genetic defects.[4]The article cites that for women the age of 35 is a benchmark in determining the age of increasing escalation of genetic defect risks and that now men can assume a doubling of the mutation rate every 16 years.
  1. ^ a b [1]Definition of advanced paternal age.
  2. ^ [2]Autism Risk Across Generations.
  3. ^ Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G, Gudjonsson SA, Sigurdsson A, Jonasdottir A, Jonasdottir A, Wong WS, Sigurdsson G, Walters GB, Steinberg S, Helgason H, Thorleifsson G, Gudbjartsson DF, Helgason A, Magnusson OT, Thorsteinsdottir U, Stefansson K (2012). "Rate of de novo mutations and the importance of father's age to disease risk". Nature 488 (7412): 471–5. doi:10.1038/nature11396. PMC 3548427. PMID 22914163.
  4. ^ [3]Father's Age Linked to Autism.

Wilson.3308 (talk) 04:07, 30 September 2014 (UTC)

In the History section of the article, a more developed history of how the Paternal Age Effect was discovered, came about could be included. In the Notable Conditions and Diseases section, many diseases are listed at the bottom without explanation. If enough information is available, more common conditions and diseases should be elaborated on, namely cataracts, heart defects, hemophilia, Klinefelter's Syndrome. Go more in-depth in the Semen & Sperm Abnormalities section, taking more about the actual studies that were preformed and the results they had. Also include aneuploidy as potential abnormality.

I agree that Autism Spectrum Disorder and Bipolar Disorder are missing links to the Wiki pages in the Notable Conditions and Diseases section. Is a free full text available for your citation on the aneuploidy study? And caution, the word performed is not spelled correctly in your edit change. Wilson.3308 (talk) 04:01, 5 October 2014 (UTC)
I Thank you for the feedback. I've gone and corrected the error. I'm still trying to find the full text for the article. — Preceding unsigned comment added by Collins.1128 (talkcontribs) 02:44, 15 October 2014 (UTC)

RASopathies such as achondroplasia and Noonan are not mentioned.


Nuevas aficiones (7984692236).jpg
I would like to add the following image to the article to help portray the meaning and improve upon the page.Wilson.3308 (talk) 02:57, 11 October 2014 (UTC)


As per my assignment, I have edited the previous "other conditions" section. It is now labeled (PAE) Disorders, mechanism, and other conditions. This edit lists the disorders collectively known as (PAE) disorders and briefly mentions the "Selfish Selection" mechanism as outlined by Goriely A, and Wilkie AOM (2013). Also, so as to not have the disorders listed twice, I have removed these (PAE) disorders from the long list of other conditions that follow. Wilson.3308 (talk) 00:49, 20 November 2014 (UTC)

Article is poor[edit]

Refs need to be improved per WP:MEDRS. Doc James (talk · contribs · email) 06:16, 12 December 2014 (UTC)