Talk:Propanoic acid

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Delisting from GA[edit]

No statement of references, so I'm delisting this article from the Good Article list. References are required to become a GA.

Diagram[edit]

I think the diagram is a bit unclear. In the first place: is it correct? It should have 3 carbons, but I see only one.

This is due to the "line-angle" formula style- all three are there. I will be drawing a bigger picture for this page very soon. Walkerma 16:57, 15 July 2005 (UTC)

(Minor) outstanding issues[edit]

  • Are we sure that the production of propionic acid as a byproduct of acetic acid manufacture is that minor? BP Chemicals keeps an outdated acetic acid plant near Kingston upon Hull (UK) open simply because of the high value of the byproducts (of which EtCOOH is by far the most important). Acetic acid production even by methanol carbonylation typically produces 1% EtCOOH (which would be 40 kt/a globally). Physchim62 11:00, 15 July 2005 (UTC)
    • The latest Kirk-Othmer (late 90s) says that propionaldehyde oxidation is the principal route to propionic acid, and gives the old butane oxidation route to acetic acid little more than a couple sentences. If I had to guess, I'd say the market supports a few of the old plants profitably, but not as the principal production route. A lot of multiple-product processes face this problem; a few producers can get away with it, but the bulk of producers are unwilling to face demand uncertainty for two products rather than just one. Shimmin 12:31, July 15, 2005 (UTC)
  • Does the halogenation of propionic acid replace the methyl hydrogens or merely the methylene hydrogens: I suspect it only replaces the CH2 hydrogens. Physchim62 11:03, 15 July 2005 (UTC)
    • Halogenation alpha to the carboxyl group (-CH2-) is most likely. I do believe that halogenation of the primary carbon (CH3-) is more difficult and only possible after the alpha-carbon is fully halogenated. Question: Why do we care about halogenation of propionic acid? ~K 15:09, 15 July 2005 (UTC)
      • I propose we change "very minor" to "minor". The Monsanto process (which we are talking about here) is still one of the major production methods in use, according to a recent (2001?) review article, and so EtCOOH must be produced in significant quantities this way- I don't think the newer Ir/Ru process has fully displaced it by any means. I have a recent student term paper on acetic acid production at home if people need some figures. And K is right, alpha halogenation is really the only significant reaction- but I am more sure of the HVZ reaction, I amended the page accordingly- feel free to make further changes. I think I will put together a stub on the HVZ, we need one, and the PBr3 page already has a scheme.Walkerma 16:54, 15 July 2005 (UTC)
    • Acetic acid production is about 5.5 Mt/a, of which about 3.5 Mt/a is by the Monsanto process and 1 Mt/a by Cativa (Ir/Ru). This gves a figure of about 40 kt/a EtCOOH as a Monsanto byproduct and over 100 kt/a from the two butane oxidation plants mentioned above. The question is: what is the annual consumption of propionic acid? 1000 kt/a (wild guess)? Physchim62 15:42, 16 July 2005 (UTC)

Merge request[edit]

I request you NOT merge the Propionic acid chemdata supplement with propionic acid. If you feel you have a valid reason to merge them, please discuss it with the WikiProject Chemicals. ~K 05:50, 6 November 2005 (UTC)

propionic acid linked to autism[edit]

A study from the University of Western Ontario has found that propionic acid may be a trigger for autism and that cutting out foods with propionic acid (especially dairy and wheat) benefits people with the disorder.

http://www.cbc.ca/health/story/2007/09/27/autism-study.html —Preceding unsigned comment added by Rathmussen (talkcontribs) 03:09, 28 September 2007 (UTC)

Propionic Acid increases HDL levels[edit]

Propionic acid induces the expression of nuclear receptors PPARα: a potential effect on HDL level.

Ibuprofen, which has been shown to raise HDL levels in healthy individuals, is a derivative of propionic acid. Because of this, researches examined the effects PPARα mRNA expression with propionic levels and concluded that propionic acid may play an important role in PPARα mRNA expression, with further effects on HDL levels. Propionic acid is produced during bacterial fermentation of fiber in the human colon and the researchers observed that L. plantarum 299v diet supplementation significantly increased HDL cholesterol in healthy subjects. —Preceding unsigned comment added by 174.16.25.19 (talk) 05:15, 23 July 2009 (UTC)

Well if you have a review that discusses this effect, please include that material into the article. Usually Wikipedia is not vying to become a forum for cutting edge research, especially in the biomedical areas. --Smokefoot (talk) 14:32, 13 July 2014 (UTC)

requested move[edit]

Move discussion in progress[edit]

There is a move discussion in progress on Talk:Propanoate which affects this page. Please participate on that page and not in this talk page section. Thank you. —RMCD bot 21:00, 20 December 2014 (UTC)